138430-85-0

Basic information

• Product Name: 3-Piperidinol, 3-(3-chloropyrazinyl)-1-methyl-
• CAS NO: 138430-85-0
• Molecular Formula: C10H14ClN3O
• Molecular Weight: 227.694
• Mol File: 138430-85-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-Piperidinol, 3-(3-chloropyrazinyl)-1-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Piperidinol, 3-(3-chloropyrazinyl)-1-methyl-(138430-85-0)
• EPA Substance Registry System: 3-Piperidinol, 3-(3-chloropyrazinyl)-1-methyl-(138430-85-0)

Safety Data

• Hazardous Substances Data: 138430-85-0(Hazardous Substances Data)

Upstream product

• 768-66-1 2,2,6,6-tetramethyl-piperidine 
• 5519-50-6 1-methyl-3-piperidone 
• 14508-49-7 2-chloropyrazin 

Relevant articles and documents

AZACYCLIC OR AZABICYCLIC COMPOUNDS, THEIR PREPARATION AND USE

The present invention relates to therapeutically active azacyclic or azabicyclic compounds of formula (I), a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful as stimulants of the cognitive function of the forebrain and hippocampus of mammals and especially in the treatment of Alzheimer's disease. (A), (B) or (C), wherein R and R1 are as defined in claim 1.

Novel functional M1 selective muscarinic agonists. 2. Synthesis and structure-activity relationships of 3-pyrazinyl-1,2,5,6-tetrahydro-1- methylpyridines. Construction of a molecular model for the M1 pharmacophore

A series of 3-(3-substituted-pyrazinyl)-1,2,5,6-tetrahydro-1- methylpyridines were synthesized and found to have high affinity for central muscarinic receptors. The ability of some of these compounds to inhibit the electrically stimulated twitch of the guinea pig vas deferens indicated that the compounds were M1 agonists. M1 agonist activity was related to the length of the side chain attached to the pyrazine ring, with maximal activity being obtained with the hexyloxy side chain. The (hexyloxy)pyrazine 3f lacked M2 agonist activity as it failed to affect the guinea pig atria and was also relatively devoid of M3 agonist activity as determined by its lack of tremorogenic and sialogogic effects in mice. A comparison of the M1 agonist efficacy of these pyrazines and related 1,2,5-thiadiazoles and 1,2,5- oxadiazoles suggested that M1 efficacy was related to the magnitude of electrostatic potential located over the nitrogens of the respective heterocycles. The heteroatom directly attached to the 3 position of the pyrazine or 1,2,5-thiadiazole heterocycle markedly influenced the M1 efficacy of the compounds by determining the energetically favorably conformers for rotation about the bond connecting the tetrahydropyridyl ring and the heterocycle. A three-dimensional model for the M1-activating pharmacophore was proposed based on computational studies and the model of the muscarinic pharmacophore proposed by Schulman.