138436-23-4

Basic information

• Product Name: (R)-(E)-1-<(tert-Butyldimethylsilyl)oxy>-2-<<<(p-methoxybenzyl)oxy>methoxy>methyl>-5-methylhex-3-ene
• Synonyms: (R)-(E)-1-<(tert-Butyldimethylsilyl)oxy>-2-<<<(p-methoxybenzyl)oxy>methoxy>methyl>-5-methylhex-3-ene
• CAS NO: 138436-23-4
• Molecular Weight: 408.654
• Mol File: 138436-23-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (R)-(E)-1-<(tert-Butyldimethylsilyl)oxy>-2-<<<(p-methoxybenzyl)oxy>methoxy>methyl>-5-methylhex-3-ene(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(E)-1-<(tert-Butyldimethylsilyl)oxy>-2-<<<(p-methoxybenzyl)oxy>methoxy>methyl>-5-methylhex-3-ene(138436-23-4)
• EPA Substance Registry System: (R)-(E)-1-<(tert-Butyldimethylsilyl)oxy>-2-<<<(p-methoxybenzyl)oxy>methoxy>methyl>-5-methylhex-3-ene(138436-23-4)

Safety Data

• Hazardous Substances Data: 138436-23-4(Hazardous Substances Data)

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 
• 226926-94-9 Acetic acid (E)-(R)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5-methyl-hex-3-enyl ester 
• 133575-94-7 Acetic acid (E)-(S)-2-hydroxymethyl-5-methyl-hex-3-enyl ester 
• 138435-98-0 diethyl (E)-2-(3-methyl-1-butene-1-yl)malonate 
• 51615-30-6 diethyl 2-(3-methylbutylidene)malonate 
• 155489-75-1 (2R,3E)-2-(hydroxymethyl)-5-methylhex-3-enyl acetate 
• 88023-78-3 para-methoxybenzyl chloride 
• 138513-53-8 (R)-(E)-2-<<(tert-Butyldimethylsilyl)oxy>methyl>-5-methylhex-3-en-1-ol 
• 590-86-3 isovaleraldehyde 
• 133490-81-0 (E)-1-Acetoxy-2-(acetoxymethyl)-5-methyl-3-hexene 
• 138436-01-8 (E)-2-(3-methyl-1-buten-1-yl)-1,3-propanediol 

Downstream Products

• 140479-45-4 (2R,3S)-1-(tert-Butyl-dimethyl-silanyloxy)-2-(4-methoxy-benzyloxymethoxymethyl)-hex-5-en-3-ol 
• 152996-70-8 (2S,3R)-N-Benzyloxy-2-(4-methoxy-benzyloxymethoxymethyl)-3-triisopropylsilanyloxy-butyramide 
• 152996-68-4 (2R,3R)-1-<<(t-butyldimethyl)silyl>oxy>-2-<<<(p-methoxybenzyl)oxy>methoxy>methyl>-3-<(tri-i-propylsilyl)oxy>butane 
• 152996-69-5 (2S,3R)-2-<<<(p-methoxybenzyl)oxy>methoxy>methyl>-3-<(tri-i-propylsilyl)oxy>butan-1-ol 
• 152996-67-3 (2R,3R)-4-<<(t-butyldimethyl)silyl>oxy>-3-<<<(p-methoxybenzyl)oxy>methoxy>methyl>-2-butanol 
• 140479-42-1 (2R,3R)-1-(tert-Butyl-dimethyl-silanyloxy)-2-(4-methoxy-benzyloxymethoxymethyl)-hex-5-en-3-ol 
• 152669-39-1 (R)-3-<<(t-butyldimethyl)silyl>oxy>-2-<<<(p-methoxybenzyl)oxy>methoxy>methyl>-1-propanol 
• 138436-28-9 (R)-3-<<(t-butyldimethyl)silyl>oxy>-2-<<<(p-methoxybenzyl)oxy>methoxy>methyl>-propanal 

Relevant articles and documents

Convergent synthesis of a key intermediate for hypocholesterolemic agent 1233A, starting from methyl 3-hydroxy-2-methylpropanoate and asymmetrized bis(hydroxymethyl)acetaldehyde (BHYMA*)

Compound 2, which is a known intermediate for the total synthesis of hypocholesterolemic agent 1233A 1, has been synthesized in good overall yield through a convergent approach, employing 3-hydroxy-2-methylpropanoate 6 and BHYMA* 5 as chiral building bloc

Protecting group controlled diastereoselective allylation of asymmetrized bis (hydroxymethyl) acetaldehydes (BHYMA)

MgBr2 catalysed allylation of a series of diprotected asymmetrized bis (Hydroxymethyl) acetaldehydes 2 with allyltributylstannane proceeds with good diastereoselectivity. The stereochemical results are in line with a cyclic chelated transition state, where only one of the two CH2OR appendages, due to the different nature of protecting groups, is capable of coordinating the Lewis acid.