1384516-20-4Relevant articles and documents
Compound with high affinity with orphan nuclear hormone receptor [alpha], and preparation method and application thereof
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, (2021/05/01)
The invention provides a compound with high affinity with an orphan nuclear hormone receptor [alpha], and a preparation method and application thereof, and belongs to the field of organic synthesis. The structural formula of the compound with high affinity with the orphan nuclear hormone receptor [alpha] is shown as a formula I, wherein A is an ester group. The compound with high affinity with the orphan nuclear hormone receptor [alpha] not only has high affinity with the orphan nuclear hormone receptor [alpha], but also can reduce cell viability, change cell metabolism, change gene transcription in hepatocytes and embryonic stem cells lacking REV-ERB[alpha]. The preparation method of the compound with high affinity with the orphan nuclear hormone receptor [alpha] is simple, raw materials are easy to obtain, and the compound can be used for treating various diseases related to the orphan nuclear hormone receptor [alpha] and has a wide application prospect.