1384665-24-0

Basic information

• Product Name: 4-fluoro-2-{6-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]imidazo[1,2-a]pyrimidin-5-yl}phenol
• Synonyms: 4-fluoro-2-{6-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]imidazo[1,2-a]pyrimidin-5-yl}phenol
• CAS NO: 1384665-24-0
• Molecular Weight: 359.408
• Mol File: 1384665-24-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-fluoro-2-{6-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]imidazo[1,2-a]pyrimidin-5-yl}phenol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-fluoro-2-{6-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]imidazo[1,2-a]pyrimidin-5-yl}phenol(1384665-24-0)
• EPA Substance Registry System: 4-fluoro-2-{6-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]imidazo[1,2-a]pyrimidin-5-yl}phenol(1384665-24-0)

Safety Data

• Hazardous Substances Data: 1384665-24-0(Hazardous Substances Data)

Upstream product

• 7720-39-0 1H-imidazol-2-amine 
• 1384665-31-9 6-fluoro-3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]-4H-1-benzopyran-4-one 

Relevant articles and documents

Synthesis of novel disubstituted pyrazolo[1,5-a]pyrimidines, imidazo[1,2-a]pyrimidines, and pyrimido[1,2-a]benzimidazolescontaining thioether and aryl moieties

A series of novel 6-[(1,3,4-thiadiazol-2-yl)sulfanyl]-7-phenylpyrazolo[1,5- a]pyrimidines, 5-phenyl-6-[(1,3,4-thiadiazol-2-yl)sulfanyl]imidazo[1,2-a] pyrimidines, and 2-phenyl-3-[(1,3,4-thiadiazol-2-yl)sulfanyl] pyrimido[1,2-a]benzimidazoles have been synthesized in four steps starting with 2-hydroxyacetophenone. The intermediate 3-[(1,3,4-thiadiazol-2-yl)sulfanyl]-4H- 1-benzopyran-4-ones reacted with pyrazol-3-amines, 5-methylpyrazol-3-amine, and 1H-imidazol-2-amine, 1H-benzimidazol-2-amine via a cyclocondensation to give the title compounds in the presence of MeONa as base, respectively. The approach affords the target compounds in acceptable-to-good yields. The new compounds were characterized by their IR, NMR, and HR mass spectra.