138485-81-1

Basic information

• Product Name: 3-(4-METHYLTHIOPHENYL)PROPIONIC ACID
• Synonyms: 3-(4-Methylthiophenyl)propionic acid 97%;3-(4-(methylmercapto)phenyl)propionic acid;3-(4-(methylthio)phenyl)propanoic acid
• CAS NO: 138485-81-1
• Molecular Formula: C₁₀H₁₂O₂S
• Molecular Weight: 196.27
• Mol File: 138485-81-1.mol
• Article Data: 6

Chemical Properties

• Melting Point: 98-102 °C(lit.)
• Boiling Point: 348.7 °C at 760 mmHg
• Flash Point: 164.7 °C
• Appearance: light yellow power
• Density: 1.19 g/cm³
• Vapor Pressure: 1.86E-05mmHg at 25°C
• Refractive Index: 1.583
• CAS DataBase Reference: 3-(4-METHYLTHIOPHENYL)PROPIONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-METHYLTHIOPHENYL)PROPIONIC ACID(138485-81-1)
• EPA Substance Registry System: 3-(4-METHYLTHIOPHENYL)PROPIONIC ACID(138485-81-1)

Safety Data

• Hazard Codes: Xi
• Statements: 41
• Safety Statements: 26-36/37/39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 138485-81-1(Hazardous Substances Data)

Usage

General Description

3-(4-methylthiophenyl)propionic acid is a chemical compound with the molecular formula C11H12O2S. It is a derivative of propionic acid and contains a substituted thiophene ring. 3-(4-METHYLTHIOPHENYL)PROPIONIC ACID is often used as a nonsteroidal anti-inflammatory drug (NSAID) due to its anti-inflammatory, analgesic, and fever-reducing properties. It is commonly used to treat conditions such as arthritis, menstrual pain, and other types of chronic pain. The presence of the methylthiophenyl group in the molecule gives the compound its specific pharmacological properties and makes it an effective and widely used medication.

InChI:InChI=1/C10H12O2S/c1-13-9-5-2-8(3-6-9)4-7-10(11)12/h2-3,5-6H,4,7H2,1H3,(H,11,12)

Upstream product

• 140134-65-2 (E)-3-<4-(methylthio)phenyl>propenoic acid 
• 2033-24-1 cycl-isopropylidene malonate 
• 3446-89-7 4-(Methylthio)benzaldehyde 
• 102016-58-0 p-(methylthio)cinnamic acid 
• 18760-11-7 4-methythiostyrene 
• 3495-36-1 cesium formate 

Downstream Products

• 138485-82-2 6-(methylthio)-1-indanone 
• 335456-27-4 N-(tert-butoxycarbonyl)-4-(methylmercapto)phenylethylamine 
• 123392-44-9 methyl 3-[4-(methylthio)phenyl]propanoate 
• 1057678-77-9 (4-(3-bromopropyl)phenyl)(methyl)sulfane 
• 116174-33-5 4-(4-methylsulfanyl-phenyl)butyric acid 
• 1026723-39-6 5-chloro-2-methoxy-N-(2-(4-methylmercaptophenyl)ethyl)benzamide 
• 335456-28-5 5-[2-(5-chloro-2-methoxybenzamido)ethyl]-2-(trifluoromethoxy)benzenesulfonamide 
• 1333406-08-8 5-(5-(4-(methylthio)phenethyl)-1,3,4-thiadiazol-2-yl)-1H-benzo[d]imidazole 
• 1527499-46-2 1-butyryl-3-(1-hydroxy-3-(4-(methylthio)phenyl)propylidene)pyrrolidine-2,4-dione 
• 651310-29-1 3-[4-(methylsulfonyl)phenyl]propan-1-ol 
• 102016-58-0 p-(methylthio)cinnamic acid 

Relevant articles and documents

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The subject matter of the invention is a process for the preparation of carboxylic acids and derivatives of them of the general formula wherein Rmeans hydrogen, or a C1 4alkyl or a (C1 5alkoxy)carbonyl group, R1is as defined in claim 1, R7stands for hydrogen or a C1 7alkyl group and R8means hydrogen or a carboxyl group, by reacting a 1,3-dioxane-4,6-dione derivative of the general formula wherein R9stands for a C1 4alkyl group or a phenyl group, optionally monosubstituted by halogen and R10stands for hydrogen or a C1 5alkyl group or R9 and R10together form a pentamethylene group, and an aldehyde or ketone of the general formula in the presence of formic acid and of [a] amine(s) and, if desired, of an alcohol of the general formula, , R7 - OH VI,, , wherein R7is a C1 7alkyl group, at a temperature of 20 to 140°C, and/or, reducing an unsaturated 1,3-dioxane-4,6-dione derivative of the general formula and/or, a 1,3-dioxane-4,6-dione derivative of the general formula with formic acid in the presence of [a] amine(s) and, if desired, of an alcohol as above defined.