1384953-87-0Relevant articles and documents
Iridium-catalyzed reduction of secondary amides to secondary amines and imines by diethylsilane
Cheng, Chen,Brookhart, Maurice
supporting information; experimental part, p. 11304 - 11307 (2012/09/05)
Catalytic reduction of secondary amides to imines and secondary amines has been achieved using readily available iridium catalysts such as [Ir(COE) 2Cl]2 with diethylsilane as reductant. The stepwise reduction to secondary amine proceeds through an imine intermediate that can be isolated when only 2 equiv of silane is used. This system requires low catalyst loading and shows high efficiency (up to 1000 turnovers at room temperature with 99% conversion have been attained) and an appreciable level of functional group tolerance.
