1384970-76-6

Basic information

• Product Name: (3aS,4R,6aR)-4-(hydroxydiphenylmethyl)-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyrrol-5-ol
• Synonyms: (3aS,4R,6aR)-4-(hydroxydiphenylmethyl)-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyrrol-5-ol
• CAS NO: 1384970-76-6
• Molecular Weight: 341.407
• Mol File: 1384970-76-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (3aS,4R,6aR)-4-(hydroxydiphenylmethyl)-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyrrol-5-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (3aS,4R,6aR)-4-(hydroxydiphenylmethyl)-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyrrol-5-ol(1384970-76-6)
• EPA Substance Registry System: (3aS,4R,6aR)-4-(hydroxydiphenylmethyl)-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyrrol-5-ol(1384970-76-6)

Safety Data

• Hazardous Substances Data: 1384970-76-6(Hazardous Substances Data)

Upstream product

• 119-61-9 benzophenone 
• 213598-45-9 3,4-isopropylidenedioxy-Δ¹-pyrroline-1-oxide 

Relevant articles and documents

A flexible enantioselective approach to 3,4-dihydroxyprolinol derivatives by SmI2-mediated reductive coupling of chiral nitrone with ketones/aldehydes

A flexible enantioselective approach to polyhydroxylated prolinol derivatives was described, which is based on the samarium diiodide-mediated reductive coupling of the chiral nitrone (3S,4R)-8, derived from d-isoascorbic acid with aldehydes/ketones. Thereby, polyhydroxyprolinol derivatives 9a-e and 9h-j were obtained from aromatic ketones and aliphatic aldehydes in good to excellent yields of 65-91%. These reductive hydroxyalkylations are highly diastereoselective in establishing the C-4 stereogenic center. By this way, the asymmetric syntheses of (-)-8a-epi-swainsonine (4) and (-)-8,8a-di-epi- swainsonine (5) have been achieved.