1385068-21-2

Basic information

• Product Name: 2,4-diamino-10-(4-chlorophenyl)-5,6,7,8,9,10-hexahydro-6-oxo-5-p-tolylbenzo[b][1,8]naphthyridine-3-carbonitrile
• Synonyms: 2,4-diamino-10-(4-chlorophenyl)-5,6,7,8,9,10-hexahydro-6-oxo-5-p-tolylbenzo[b][1,8]naphthyridine-3-carbonitrile
• CAS NO: 1385068-21-2
• Molecular Weight: 455.947
• Mol File: 1385068-21-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2,4-diamino-10-(4-chlorophenyl)-5,6,7,8,9,10-hexahydro-6-oxo-5-p-tolylbenzo[b][1,8]naphthyridine-3-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-diamino-10-(4-chlorophenyl)-5,6,7,8,9,10-hexahydro-6-oxo-5-p-tolylbenzo[b][1,8]naphthyridine-3-carbonitrile(1385068-21-2)
• EPA Substance Registry System: 2,4-diamino-10-(4-chlorophenyl)-5,6,7,8,9,10-hexahydro-6-oxo-5-p-tolylbenzo[b][1,8]naphthyridine-3-carbonitrile(1385068-21-2)

Safety Data

• Hazardous Substances Data: 1385068-21-2(Hazardous Substances Data)

Upstream product

• 36646-75-0 3-(4-choloroaniline)-2-cyclohexen-1-one 
• 104-87-0 4-methyl-benzaldehyde 
• 868-54-2 1,1,3-tricyano-2-amino-1-propene 

Relevant articles and documents

New domino heteroannulation of enaminones: Synthesis of diverse fused naphthyridines

A series of new poly-functionalized fused naphthyridine derivatives were synthesized via a three-component reaction of aldehyde, 2-aminoprop-1-ene-1,1,3- tricarbonitrile and enaminone in EtOH using EtONa as a base. During these reaction processes, the domino construction of fused naphthyridine skeleton with concomitant formation of two new pyridine rings was readily achieved via base promoted three-component reactions in a one-pot operation. The procedures are facile, avoiding time-consuming and costly syntheses, tedious work-up and purifications of precursors.