13856-87-6

Basic information

• Product Name: Benzenemethanol, a-butyl-4-chloro-
• CAS NO: 13856-87-6
• Molecular Formula: C11H15ClO
• Molecular Weight: 198.692
• Mol File: 13856-87-6.mol
• Article Data: 16

Chemical Properties

• CAS DataBase Reference: Benzenemethanol, a-butyl-4-chloro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanol, a-butyl-4-chloro-(13856-87-6)
• EPA Substance Registry System: Benzenemethanol, a-butyl-4-chloro-(13856-87-6)

Safety Data

• Hazardous Substances Data: 13856-87-6(Hazardous Substances Data)

Upstream product

• 25017-08-7 1-(4-chlorophenyl)pentan-1-one 
• 71-23-8 propan-1-ol 
• 3391-10-4 1-(p-chlorophenyl)ethyl alcohol 
• 7335-27-5 ethyl 4-chlorobenzoate 
• 693-04-9 butyl magnesium bromide 
• 13940-94-8 (4-chlorophenyl)dichloromethane 
• 109-72-8 n-butyllithium 
• 104-88-1 4-chlorobenzaldehyde 
• 122-56-5 tributyl borane 
• 19350-69-7 4-chlorobenzaldehyde p-toluenesulfonylhydrazone 
• 109-65-9 1-bromo-butane 
• 693-03-8 n-butyl magnesium bromide 
• 18987-26-3 trimethyltelluronium iodide 

Downstream Products

• 15954-52-6 p-Chlor-β-butyl-hydrozimtsaeure 
• 50673-59-1 Bernsteinsaeure-mono-<1-(4-chlorphenyl)-pentyl>-ester 
• 50673-77-3 Pentanedioic acid mono-[1-(4-chloro-phenyl)-pentyl] ester 
• 25017-08-7 1-(4-chlorophenyl)pentan-1-one 
• 18654-74-5 (E)-1-chloro-4-(pent-1-en-1-yl)benzene 
• 426215-79-4 4-(4-chloro-phenyl)-5-propyl-thiazol-2-ylamine 

Relevant articles and documents

Control of enantioselectivity in the enzymatic reduction of halogenated acetophenone analogs by substituent positions and sizes

We utilized acetophenone reductase from Geotrichum candidum NBRC 4597 (GcAPRD), wild type and Trp288Ala mutant, to reduce halogenated acetophenone analogs to their corresponding (S)- and (R)-alcohols beneficial as pharmaceutical intermediates. Reduction by wild type resulted in excellent (S)-enantioselectivity for all of the substrates tested. Meanwhile, reduction by Trp288Ala resulted in high (R)-enantioselectivity for the reduction of 4′ substituted acetophenone and 2′-trifluoromethylacetophenone. In addition to that, we were able to control the enantioselectivity of Trp288Ala by the positions and sizes of the halogen substituents.

Catalytic asymmetric addition of alkyllithium reagents to aromatic aldehydes

Herein, we report the first efficient catalytic system for the asymmetric alkylation of aldehydes with organolithium reagents in the presence of titanium(IV) isopropoxide. A variety of alkyllithium reagents can be added to aromatic aldehydes in good yields with high enantioselectivities in a simple one-pot procedure under mild conditions. Herein, we report the first efficient catalytic system for the asymmetric alkylation ofaldehydes with organolithium reagents in the presence of titanium(IV) isopropoxide. A variety of alkyllithium reagents can be added to aromatic aldehydes in good yields with high enantioselectivities in a simple one-pot procedure under mild conditions. Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Efficient chemoselective addition of grignard reagents to carbonyl compounds in 2-methyltetrahydrofuran

Compared with tetrahydrofuran (THF) as a solvent for the addition reactions between Grignard reagents and carbonyl compounds 2-methyltetrahydrofuran affords the corresponding adducts in higher yields with higher chemoselectivities. Moreover, 2-methyltetrahydrofuran can be readily recycled and reused, which lowers the cost of the process and makes the reaction greener.