138624-99-4

Basic information

• Product Name: 2,2,2-Trifluoro-1-(pyridin-3-yl)ethanol
• Synonyms: 2,2,2-Trifluoro-1-(pyridin-3-yl)ethanol
• CAS NO: 138624-99-4
• Molecular Formula: C7H6F3NO
• Molecular Weight: 177.1238496
• Mol File: 138624-99-4.mol
• Article Data: 10

Chemical Properties

• Appearance: /Solid
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2,2,2-Trifluoro-1-(pyridin-3-yl)ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2,2-Trifluoro-1-(pyridin-3-yl)ethanol(138624-99-4)
• EPA Substance Registry System: 2,2,2-Trifluoro-1-(pyridin-3-yl)ethanol(138624-99-4)

Safety Data

• Hazardous Substances Data: 138624-99-4(Hazardous Substances Data)

Usage

General Description

2,2,2-Trifluoro-1-(pyridin-3-yl)ethanol is a fluorinated alcohol compound with the chemical formula C7H6F3NO. It is a colorless liquid with a molecular weight of 163.12 g/mol. 2,2,2-Trifluoro-1-(pyridin-3-yl)ethanol is commonly used as a building block in the production of pharmaceuticals, agrochemicals, and other organic compounds. It is known for its ability to introduce the trifluoromethyl group into various molecules, which can enhance their biological activity and chemical stability. Additionally, 2,2,2-Trifluoro-1-(pyridin-3-yl)ethanol is used as a solvent and reagent in organic synthesis processes. It should be handled and stored with proper safety precautions due to its flammability and potential health hazards.

Upstream product

• 626-55-1 3-Bromopyridine 
• 75-90-1 2,2,2-Trifluoroacetaldehyde 
• 500-22-1 3-pyridinecarboxaldehyde 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 1120-90-7 3-iodopyridine 
• 807329-97-1 TurboGrignard 
• 407-38-5 2,2,2-trifluoroethyl trifluoroacetate 

Downstream Products

• 33284-21-8 3-(trifluoroacetyl)pyridine 
• 1099598-09-0 3-(2,2,2-trifluoroethyl)pyridine 

Relevant articles and documents

Fungicidal Pyridine Derivatives, IV. α-Trifluoromethyl-3-pyridinemethanols

The synthesis of a series of the title compounds is described applying the addition of 3-pyridyllithium to appropriate trifluoromethylalkanones (path 1) and addition of lithiumorganyls to 2,2,2-trifluoro-1-(3-pyridyl)-ethanone (path 2), respectively.Keywords.Fungicides; α-Trifluoromethyl-pyridinemethanols.

One-Pot Successive Turbo Grignard Reactions for the Facile Synthesis of α-Aryl-α-Trifluoromethyl Alcohols

A novel straightforward one-pot methodology for two successive turbo Grignard reagent (iPrMgCl·LiCl) reactions, was developed for a facile synthesis of α-aryl-α-trifluoromethyl alcohols, motifs of value in pharmaceutical chemistry. The method displayed broad functional group tolerance, including reducible groups. Dual roles of iPrMgCl·LiCl were exploited in the tandem reaction with commercially available iodoarenes or iodoheteroarenes and 2,2,2-trifluoroethyl trifluoroacetate. The process encompasses three successive reactions in a one-pot process: the iPrMgCl·LiCl-mediated iodine/magnesium-exchange reaction of iodoarenes or iodoheteroarenes; nucleophilic addition of various generated aryl or heteroarylmagnesium reagents to 2,2,2-trifluoroethyl trifluoroacetate; and the reduction of in-situ generated aryl trifluoromethyl ketones with iPrMgCl·LiCl, to produce the corresponding α-aryl or α-heteroaryl-α-trifluoromethyl alcohols bearing various substituents, including reducible functional groups in good to excellent yields.

TETRAHYDRONAPHTHYRIDINE DERIVATIVES AS mGluR2-NEGATIVE ALLOSTERIC MODULATORS, COMPOSITIONS, AND THEIR USE

Provided are quinoline carboxamide and quinoline carbonitrile compounds of formula (I) or a pharmaceutically acceptable salt thereof, wherein R 1, R 2, L, X 1, X 2, and X 3, are as defined herein. The compounds of the invention, and pharmaceutically acceptable salts thereof, and pharmaceutical compositions comprising them, are useful as non-competitive mGluR2 antagonists, or mGluR2 negative allosteric modulators (NAMs), and may be useful in methods of treating a person in need thereof for diseases or disorders in which the mGluR2-NAM receptor plays a causative role, such as Alzheimer's disease, cognitive impairment, schizophrenia and other mood disorders, pain disorders and sleep disorders.