13864-49-8

Basic information

• Product Name: 5(10)-estrene-3α,17β-diol
• CAS NO: 13864-49-8
• Molecular Weight: 276.419
• Mol File: 13864-49-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5(10)-estrene-3α,17β-diol(CAS DataBase Reference)
• NIST Chemistry Reference: 5(10)-estrene-3α,17β-diol(13864-49-8)
• EPA Substance Registry System: 5(10)-estrene-3α,17β-diol(13864-49-8)

Safety Data

• Hazardous Substances Data: 13864-49-8(Hazardous Substances Data)

Upstream product

• 3962-66-1 estra-5⁽¹⁰⁾-en-3,17-dione 
• 1089-78-7 17β-hydroxy-estr-5(10)-en-3-one 

Relevant articles and documents

An easy stereoselective synthesis of 5(10)-estrene-3β,17α-diol, a biological marker of pregnancy in the mare

5(10)-Estrene-3β,17α-diol is an essential reference material for doping analysis in horse-racing laboratories. It is used to detect misuse, for doping purpose, of the pregnancy status in the mare. Its stereoselective synthesis from 17β-estradiol-3-methyl ether (prepared from estrone or 17β-estradiol) was performed in four steps: (1) Mitsunobu inversion of the 17β-alcohol; (2) Birch reduction of the aromatic ring; (3) stereoselective reduction of the 3-ketone via Noyori asymmetric transfer hydrogenation; (4) chemoenzymatic purification.

Steroid series. XVII. New synthetic routes to 19-norsteroids.

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