138642-93-0Relevant articles and documents
Novel compounds
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Paragraph 0080, (2017/09/27)
The present invention relates to novel retinoid-related orphan receptor gamma (RORγ) modulators and their use in the treatment of diseases mediated by RORγ.
NEW CHEMICAL COMPOUNDS
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Page/Page column 39, (2009/03/07)
The present invention encompasses compounds of general formula (1) wherein the groups R2 to R4, L, Q and n are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and their use for preparing a pharmaceutical composition with the above-mentioned properties.
Regioselective Hydrolysis of Aromatic Dinitriles Using a Whole Cell Catalyst
Crosby, John,Moilliet, Jock,Parratt, Julian S.,Turner, Nicolas J.
, p. 1679 - 1688 (2007/10/02)
A series of aromatic dinitriles have been examined as substrates for an immobilised whole cell Rhodococcus sp. that catalyses the hydrolysis of nitriles to amides and/or carboxylic acids.The fluorinated aromatic dinitriles 48 and 49 were regioselectively hydrolysed to the corresponding cyano amides 48a and 49a whereas the non-fluorinated analogues 41-44 were converted to cyano acids but with poorer regioselectivity.
