138647-05-9

Basic information

• Product Name: 2-bromo-2-(2-chlorophenyl)acetyl chloride
• Synonyms: 2-bromo-2-(2-chlorophenyl)acetyl chloride
• CAS NO: 138647-05-9
• Molecular Weight: 267.937
• Mol File: 138647-05-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-bromo-2-(2-chlorophenyl)acetyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-bromo-2-(2-chlorophenyl)acetyl chloride(138647-05-9)
• EPA Substance Registry System: 2-bromo-2-(2-chlorophenyl)acetyl chloride(138647-05-9)

Safety Data

• Hazardous Substances Data: 138647-05-9(Hazardous Substances Data)

Upstream product

• 86169-24-6 2-amino-(2-chlorophenyl)ethanoic acid 
• 29270-30-2 α-bromo-2-chlorophenyl acetic acid 
• 2444-36-2 2'-chloro-benzeneacetic acid 
• 51512-09-5 2-(2-chlorophenyl)acetyl chloride 

Downstream Products

• 1092477-55-8 (+/-)-N'-[3,5-bis(trifluoromethyl)phenyl]-2-(2-chlorophenyl)-2-(1-piperazinyl)acetohydrazide 
• 120202-66-6 (S)-(+)-clopidogrel bisulfate 
• 113665-84-2 (S)-(+)-clopidogrel 
• 1345668-93-0 4-benzyl-6-(2-chlorophenyl)-5-oxo-4,5-dihydropyrazine-2-carbaldehyde 
• 1345668-80-5 N-allyl-2-azido-N-benzyl-2-(2-chlorophenyl)acetamide 
• 1345669-15-9 N-allyl-N-benzyl-2-bromo-2-(2-chlorophenyl)acetamide 
• 1092477-38-7 (+/-)-N'-[3,5-bis(trifluoromethyl)phenyl]-2-(2-chlorophenyl)-2-(4-methyl-1-piperazinyl)acetohydrazide 
• 85259-20-7 5-(2-chlorophenyl)-2-imino-1,3-thiazolidin-4-one 
• 82124-33-2 5-(2-chlorophenyl)thiazolidine-2,4-dione 
• 85259-19-4 methyl 2-bromo-2-(2-chlorophenyl)acetate 

Relevant articles and documents

Benzoxazinone-containing 3,5-dimethylisoxazole derivatives as BET bromodomain inhibitors for treatment of castration-resistant prostate cancer

The bromodomain and extra-terminal proteins (BET) have emerged as promising therapeutic targets for the treatment of castration-resistant prostate cancer (CRPC). We report the design, synthesis and evaluation of a new series of benzoxazinone-containing 3,5-dimethylisoxazole derivatives as selective BET inhibitors. One of the new compounds, (R)-12 (Y02234), binds to BRD4(1) with a Kd value of 110 nM and blocks bromodomain and acetyl lysine interactions with an IC50 value of 100 nM. It also exhibits selectivity for BET over non-BET bromodomain proteins and demonstrates reasonable anti-proliferation and colony formation inhibition effect in prostate cancer cell lines such as 22Rv1 and C4-2B. The BRD4 inhibitor (R)-12 also significantly suppresses the expression of ERG, Myc and AR target gene PSA at the mRNA level in prostate cancer cells. Treatment with (R)-12 significantly suppresses the tumor growth of prostate cancer (TGI = 70%) in a 22Rv1-derived xenograft model. These data suggest that compound (R)-12 is a promising lead compound for the development of a new class of therapeutics for the treatment of CRPC.

Copper(II)-catalyzed synthesis of pyrazinones from α-Azido-N- allylamides under an oxygen atmosphere

A copper(II)-catalyzed reaction of -azido-N-allylamide synthetic under an oxygen atmosphere resulted in the formation of 2-formyl pyrazinones. The present transformation was characterized by the following steps: 1) 1,3-dipolar cycloaddition of the azido part onto the intramolecular alkene to give bicyclic aziridine intermediates; 2) further copper(II)-catalyzed oxygenation-oxidation of the aziridines to give 2-formyl pyrazinones. Georg Thieme Verlag Stuttgart · New York.

Studies on antidiabetic agents. III. 5-arylthiazolidine-2,4-diones as potent aldose reductase inhibitors

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