13865-20-8

Basic information

• Product Name: Propanoic acid, 2,2-diMethyl-3-oxo-, Methyl ester
• Synonyms: Propanoic acid, 2,2-diMethyl-3-oxo-, Methyl ester;Methyl 2,2-diMethyl-3-oxopropanoate;EOS-61586
• CAS NO: 13865-20-8
• Molecular Formula: C₆H₁₀O₃
• Molecular Weight: 130.1418
• Mol File: 13865-20-8.mol
• Article Data: 47

Chemical Properties

• Boiling Point: 49-50 °C(Press: 12 Torr)
• Appearance: /
• Density: 1.013±0.06 g/cm3(Predicted)
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• Solubility: Chloroform (Slightly)
• Stability: Hygroscopic
• CAS DataBase Reference: Propanoic acid, 2,2-diMethyl-3-oxo-, Methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Propanoic acid, 2,2-diMethyl-3-oxo-, Methyl ester(13865-20-8)
• EPA Substance Registry System: Propanoic acid, 2,2-diMethyl-3-oxo-, Methyl ester(13865-20-8)

Safety Data

• Hazardous Substances Data: 13865-20-8(Hazardous Substances Data)

Usage

General Description

Propanoic acid, 2,2-dimethyl-3-oxo-, methyl ester is a chemical compound with the molecular formula C7H12O3. Commonly known as methyl 2,2-dimethyl-3-oxopropionate, it is a colorless liquid that is used in various industries as a solvent, flavoring agent, and intermediate in the production of pharmaceuticals and agrochemicals. It is also used in the synthesis of other organic compounds and can be found in some insect repellents. This chemical compound is considered to be relatively stable and has low toxicity, but proper precautions should be taken when handling it to avoid skin or eye contact and inhalation of vapors. Overall, propanoic acid, 2,2-dimethyl-3-oxo-, methyl ester serves a variety of industrial applications and is important for the production of numerous consumer products.

Upstream product

• 107-31-3 Methyl formate 
• 85433-67-6 methyl lithioisobutyrate 
• 201230-82-2 carbon monoxide 
• 80-62-6 methacrylic acid methyl ester 
• 31469-15-5 1-methoxy-2-methyl-1-trimethylsiloxy-1-propene 
• 14002-80-3 Methyl 2,2-dimethyl-3-hydroxypropionate 
• 79-37-8 oxalyl dichloride 
• 73372-15-3 methyl 4-hydroxy-2-methylbutanoate 
• 110-91-8 morpholine 
• 111-92-2 dibutylamine 
• 62-53-3 aniline 
• 100-46-9 benzylamine 
• 2565-30-2 formyl chloride 
• 547-63-7 Methyl isobutyrate 

Downstream Products

• 225939-81-1 (S)-3-[N-(1'-Allyloxy-3'-phenylprop-2'-yl)imino]-2,2-dimethylpropionsaeure-methylester-N-oxid 
• 189499-00-1 2.2-dimethyl-3.3-bis(4-hydroxyphenyl)propionic acid methyl ester 
• 933039-90-8 methyl 2-[(2R,4S,6R)-6-(2-benzyloxyethyl)-4-bromotetrahydro-2H-pyran-2-yl]-2-methylpropanoate 
• 86000-11-5 methyl 2,2-dimethyl-3-(benzylamino)propionate 
• 639519-02-1 (3S,4R)-3-benzyloxy-2,2,4-trimethylhex-5-en-1-ol 
• 639519-01-0 (3S,4R)-3-benzyloxy-2,2,4-trimethylhex-5-enoic acid methyl ester 
• 224309-88-0 methyl 2,2-dimethyl-3-(piperazin-1-yl)propanoate 
• 1380094-31-4 methyl 2-[5-(2,4-difluorophenyl)-4-(6-hydroxy-5-nitro-2-pyridyl)-1H-imidazol-2-yl]-2-methyl-propanoate 
• 1380094-32-5 methyl 2-[4-(5-amino-6-hydroxy-2-pyridyl)-5-(2,4-difluorophenyl)-1H-imidazol-2-yl]-2-methyl-propanoate 
• 1380094-33-6 methyl 2-[5-(2,4-difluorophenyl)-4-[2-[[(1S)-3-methoxy-1-methyl-propyl]amino]oxazolo[5,4-b]pyridin-5-yl]-1H-imidazol-2-yl]-2-methyl-propanoate 
• 1380094-11-0 2-[5-(2,4-difluorophenyl)-4-[2-[[(1S)-3-methoxy-1-methyl-propyl]amino]oxazolo[5 ,4-b]pyridin-5-yl]-1H-imidazol-2-yl]-2-methyl-propan-1-ol 
• 1380094-12-1 2-[5-(2,4-difluorophenyl)-4-[2-[[(1S)-3-methoxy-1-methyl-propyl]amino]oxazolo[5 ,4-b]pyridin-5-yl]-1H-imidazol-2-yl]-2-methyl-propan-1-ol methanesulfonate 
• 1380094-13-2 2-[5-(2,4-difluorophenyl)-4-[2-[[(1S)-3-methoxy-1-methyl-propyl]amino]oxazolo[5 ,4-b]pyridin-5-yl]-1H-imidazol-2-yl]-2-methyl-propan-1-ol hydrochloride 
• 1398047-38-5 diethyl 4-nitrobenzylphosphonate 

Relevant articles and documents

Preparation and synthetic applications of sterically hindered secondary amines

The preparation of sterically hindered secondary amino esters from the reaction of N-protected α-amino aldehydes and 3-, or 2-oxo esters with α- amino esters by reductive amination is described. The resulting amino esters were converted to the β-lactam or acylated to form N-acyl secondary amides.

Simple alkenes as substitutes for organometallic reagents: Nickel-catalyzed, intermolecular coupling of aldehydes, silyl triflates, and alpha olefins

A nickel-catalyzed method for the three-component coupling of alkenes (ethylene and alpha olefins), aldehydes, and silyl triflates is described, and this process represents the first catalytic method for coupling aldehydes and alkenes to give allylic alco

Function-Oriented Synthesis toward Peloruside A Analogues

A convergent and rapid synthesis of original C2,C3-unsaturated, C11,C13-keto-enol macrocycles with a peloruside A skeleton has been developed. These original unsaturated macrocycles constitute valuable platforms to access peloruside A analogues with high

-

-

TRICYCLIC AKR1C3 DEPENDENT KARS INHIBITORS

The present invention relates to novel tricyclic compounds that are AKR1C3 dependent KARS inhibitor, processes for their preparation, pharmaceutical compositions, and medicaments containing them, and their use in diseases and disorders mediated by an AKR1C3 dependent KARS inhibitor.

Efficient synthesis of chiral γ-aminobutyric esters: Via direct rhodium-catalysed enantioselective hydroaminomethylation of acrylates

The successful rhodium catalysed asymmetric intermolecular hydroaminomethylation (HAM) of alkenes using a single catalyst bearing the (R,R)-QuinoxP? ligand is reported. The HAM of α-alkyl acrylates is revealed to be an efficient tool for the regio- and en