1386928-23-9

Basic information

• Product Name: 1-[2-(4-fluorophenyl)phenyl]piperazine hydrochloride
• CAS NO: 1386928-23-9
• Molecular Weight: 292.784
• Mol File: 1386928-23-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-[2-(4-fluorophenyl)phenyl]piperazine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[2-(4-fluorophenyl)phenyl]piperazine hydrochloride(1386928-23-9)
• EPA Substance Registry System: 1-[2-(4-fluorophenyl)phenyl]piperazine hydrochloride(1386928-23-9)

Safety Data

• Hazardous Substances Data: 1386928-23-9(Hazardous Substances Data)

Upstream product

• 321-63-1 4'-fluoro-biphenyl-2-ylamine 
• 821-48-7 bis-(2-chloroethyl)amine hydrochloride 
• 615-43-0 2-iodophenylamine 
• 1765-93-1 4-fluoroboronic acid 

Relevant articles and documents

Investigations on the 1-(2-biphenyl)piperazine motif: Identification of new potent and selective ligands for the serotonin7 (5-HT7) receptor with agonist or antagonist action in vitro or ex vivo

Here we report the design, synthesis, and 5-HT7 receptor affinity of a set of 1-(3-biphenyl)- and 1-(2-biphenyl)piperazines. The effect on 5-HT7 affinity of various substituents on the second (distal) phenyl ring was analyzed. Several compounds showed 5-HT7 affinities in the nanomolar range and >100-fold selectivity over 5-HT1A and adrenergic α1 receptors. 1-[2-(4-Methoxyphenyl)phenyl] piperazine (9a) showed 5-HT7 agonist properties in a guinea pig ileum assay but blocked 5-HT-mediated cAMP accumulation in 5-HT7- expressing HeLa cells.