1386928-56-8

Basic information

• Product Name: 1-[2-(2-methylphenyl)phenyl]piperazine hydrochloride
• CAS NO: 1386928-56-8
• Molecular Weight: 288.82
• Mol File: 1386928-56-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-[2-(2-methylphenyl)phenyl]piperazine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[2-(2-methylphenyl)phenyl]piperazine hydrochloride(1386928-56-8)
• EPA Substance Registry System: 1-[2-(2-methylphenyl)phenyl]piperazine hydrochloride(1386928-56-8)

Safety Data

• Hazardous Substances Data: 1386928-56-8(Hazardous Substances Data)

Upstream product

• 1203-41-4 2-(2-methylphenyl)aniline 
• 821-48-7 bis-(2-chloroethyl)amine hydrochloride 

Relevant articles and documents

Investigations on the 1-(2-biphenyl)piperazine motif: Identification of new potent and selective ligands for the serotonin7 (5-HT7) receptor with agonist or antagonist action in vitro or ex vivo

Here we report the design, synthesis, and 5-HT7 receptor affinity of a set of 1-(3-biphenyl)- and 1-(2-biphenyl)piperazines. The effect on 5-HT7 affinity of various substituents on the second (distal) phenyl ring was analyzed. Several compounds showed 5-HT7 affinities in the nanomolar range and >100-fold selectivity over 5-HT1A and adrenergic α1 receptors. 1-[2-(4-Methoxyphenyl)phenyl] piperazine (9a) showed 5-HT7 agonist properties in a guinea pig ileum assay but blocked 5-HT-mediated cAMP accumulation in 5-HT7- expressing HeLa cells.