138722-46-0

Basic information

• Product Name: 1-Propanone, 3-[4-(1,1-dimethylethyl)phenyl]-1-phenyl-
• CAS NO: 138722-46-0
• Molecular Formula: C19H22O
• Molecular Weight: 266.383
• Mol File: 138722-46-0.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: 1-Propanone, 3-[4-(1,1-dimethylethyl)phenyl]-1-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Propanone, 3-[4-(1,1-dimethylethyl)phenyl]-1-phenyl-(138722-46-0)
• EPA Substance Registry System: 1-Propanone, 3-[4-(1,1-dimethylethyl)phenyl]-1-phenyl-(138722-46-0)

Safety Data

• Hazardous Substances Data: 138722-46-0(Hazardous Substances Data)

Upstream product

• 877-65-6 p-tert-butylbenzyl alcohol 
• 98-85-1 1-Phenylethanol 
• 936-59-4 3-chloropropiophenone 
• 123324-71-0 p-tert-butylphenylboronic acid 
• 1074-12-0 phenylglyoxal hydrate 
• 1746-23-2 4-tert-Butylstyrene 
• 473543-85-0 3-(4-(tert-butyl)phenyl)-1-phenylprop-2-en-1-one 
• 939-97-9 4-tert-Butylbenzaldehyde 
• 98-86-2 acetophenone 
• 772-38-3 4-tert-Butylphenylacetylene 
• 100-51-6 benzyl alcohol 
• 132971-87-0 4'-t-Butylchalcon 
• 36952-37-1 N-(3-methylpyridin-2-yl)-1-phenylmethanimine 

Downstream Products

• 138722-44-8 1-(4-tert-butylphenyl)-3-phenylpropane 

Relevant articles and documents

Borane-Catalyzed, Chemoselective Reduction and Hydrofunctionalization of Enones Enabled by B-O Transborylation

The use of stoichiometric organoborane reductants in organic synthesis is well established. Here these reagents have been rendered catalytic through an isodesmic B-O/B-H transborylation applied in the borane-catalyzed, chemoselective alkene reduction and formal hydrofunctionalization of enones. The reaction was found to proceed by a 1,4-hydroboration of the enone and B-O/B-H transborylation with HBpin, enabling catalyst turnover. Single-turnover and isotopic labeling experiments supported the proposed mechanism of catalysis with 1,4-hydroboration and B-O/B-H transborylation as key steps.

Ligand-controlled phosphine-free Co(II)-catalysed cross-coupling of secondary and primary alcohols

Cobalt(II) complexes (5 mol% Co) bearing phosphine-free N?N?N pincer ligands efficiently catalyze C–C coupling of secondary and primary alcohols to selectively form α-alkylated ketones with a good functional group compatibility using NaOH (20 mol%) as a base at 120 °C. The NH group on the N?N?N–Co(II) precatalyst controls the activity and selectivity. This simple catalytic system is involved in the synthesis of quinolones via the dehydrogenative annulation of 2-aminobenzyl alcohols with secondary alcohols.

C?C Bond Formation of Benzyl Alcohols and Alkynes Using a Catalytic Amount of KOtBu: Unusual Regioselectivity through a Radical Mechanism

We report a C?C bond-forming reaction between benzyl alcohols and alkynes in the presence of a catalytic amount of KOtBu to form α-alkylated ketones in which the C=O group is located on the side derived from the alcohol. The reaction proceeds under thermal conditions (125 °C) and produces no waste, making the reaction highly atom efficient, environmentally benign, and sustainable. Based on our mechanistic investigations, we propose that the reaction proceeds through radical pathways.