138736-73-9 Usage
Description
HAMNO is a novel protein interaction inhibitor of replication protein A (RPA), which plays a crucial role in various cellular processes, including DNA replication, repair, and recombination. Its ability to inhibit the interaction between RPA and other proteins makes it a potential candidate for therapeutic applications, particularly in the field of cancer treatment.
Uses
Used in Cancer Treatment:
HAMNO is used as an anticancer agent for its significant inhibitory effects on colony formation when combined with etoposide. This combination therapy may enhance the efficacy of cancer treatment by targeting the replication protein A, which is essential for the survival and proliferation of cancer cells.
Used in Drug Development:
In the pharmaceutical industry, HAMNO is used as a lead compound for the development of new drugs targeting the replication protein A. Its unique mechanism of action and potential synergistic effects with other chemotherapeutic agents make it a valuable asset in the search for more effective cancer treatments.
Used in Research:
In the field of molecular biology and biochemistry, HAMNO is used as a research tool to study the role of replication protein A in various cellular processes. By inhibiting the interaction between RPA and other proteins, researchers can gain a better understanding of the molecular mechanisms underlying DNA replication, repair, and recombination, which may lead to the discovery of new therapeutic targets and strategies for cancer treatment.
Check Digit Verification of cas no
The CAS Registry Mumber 138736-73-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,8,7,3 and 6 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 138736-73:
(8*1)+(7*3)+(6*8)+(5*7)+(4*3)+(3*6)+(2*7)+(1*3)=159
159 % 10 = 9
So 138736-73-9 is a valid CAS Registry Number.
138736-73-9Relevant articles and documents
Structural investigation on phenyl- and pyridin-2-ylamino(methylene) naphthalen- 2(3H)-one. Substituent effects on the NMR chemical shifts
Venkatachalam, Taracad K.,Pierens, Gregory K.,Campitelli, Marc R.,Reutens, David C.
experimental part, p. 585 - 592 (2011/05/07)
Schiff bases bearing phenyl and pyridyl groups were synthesized by condensation of appropriate amines with 2- hydroxynaphthaldehyde. These Schiff bases were obtained as colored crystalline solids. The proton NMR spectra of these compounds showed a doublet
