138761-50-9Relevant articles and documents
Remote controlled nucleophilicity, 2: Lithiated C(α)-substituted 4-methylpyridines
Anders,Opitz,Bauer
, p. 1221 - 1227 (2007/10/02)
C(α)-substituted 4-methylpyridines have been N-lithiated and reacted with chlorotrimethylsilane and other electrophiles. The lithiated C(α)-NMe2 substituted intermediate shows an interesting dichotomy of behavior towards electrophiles: It represents the borderline between compounds for which an extreme N or C(α) regionucleophilicity is observed.