138772-68-6

Basic information

• Product Name: tert-butyl ((2S)-1-(((2R)-1-hydroxy-3-phenylpropan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate
• Synonyms: tert-butyl ((2S)-1-(((2R)-1-hydroxy-3-phenylpropan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate
• CAS NO: 138772-68-6
• Molecular Weight: 398.502
• Mol File: 138772-68-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: tert-butyl ((2S)-1-(((2R)-1-hydroxy-3-phenylpropan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl ((2S)-1-(((2R)-1-hydroxy-3-phenylpropan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate(138772-68-6)
• EPA Substance Registry System: tert-butyl ((2S)-1-(((2R)-1-hydroxy-3-phenylpropan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate(138772-68-6)

Safety Data

• Hazardous Substances Data: 138772-68-6(Hazardous Substances Data)

Upstream product

• 3182-95-4 L-Phenylalaninol 
• 51987-73-6 (S)-2-tert-butoxycarbonylamino-3-phenyl-propionic acid methyl ester 
• 5267-64-1 (R)-2-amino-3-phenylpropanol 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 3674-06-4 Boc-Phe-ONSu 
• 15215-74-4 methyl (tert-butoxycarbonyl)-L-phenylalanyl-L-phenylalaninate 

Downstream Products

• 138772-75-5 Acetic acid (R)-2-((S)-2-amino-3-phenyl-propionylamino)-3-phenyl-propyl ester; compound with trifluoro-acetic acid 
• 138772-72-2 (R)-2-((S)-2-(tert-butoxycarbonylamino)-3-phenylpropanamido)-3-phenylpropyl acetate 

Relevant articles and documents

Organobase-catalyzed amidation of esters with amino alcohols

A base-mediated procedure for the amidation of unactivated esters with amino alcohols is reported. Optimization and exemplification of the catalytic process are described, furnishing products in 40-100% isolated yield.

Simple Peptides. VII. The Chemical Conversions of C-Terminal α-Amino Acids in Peptides into Unsubstituted or 2-Substituted Taurine via S-Acetylthio- or Halogeno-Intermediates

The syntheses of ten dipeptides 5a-c, e, f, h-j, l and m, containing taurine or its 2-substituted derivatives, are described: C-terminal a-amino acids in the dipeptides were chemically converted to the taurines by two main routes.One involves the successive conversion of N-tert-butoxycarbonyl(Boc)-protected dipeptide esters 1 into the 2-(Boc-aminoacyl)aminoethanols 2 and thence into their acetylthio derivatives 4 via β-bromoethylamides 3, followed by the performic acid oxidation of the acetylthio into a sulpho group to give the deprotected taurine dipeptides 5.In the other, 2 was converted into 5 using the substitution reaction of a sulpho group for a halogen or mesyl group via the corresponding β-halogenoethyl or β-(methanesulphonyl)-oxyethyl amides, 3,9 or 7.The preparation of intrinsic γ-L-Glu-Tau (glutaurine) 12a and its D-isomer 12b from the acetylthio derivatives 11a and 11b by performic acid oxidation is also described as examples of the use of S-acetylcysteamine for a taurine precursor.