1388056-45-8

Basic information

• Product Name: 6-bromo-8-methoxy-1,2,3,4-tetrahydroquinoline
• CAS NO: 1388056-45-8
• Molecular Weight: 242.115
• Mol File: 1388056-45-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 340.3±42.0 °C(Predicted)
• Density: 1.403±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 6-bromo-8-methoxy-1,2,3,4-tetrahydroquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 6-bromo-8-methoxy-1,2,3,4-tetrahydroquinoline(1388056-45-8)
• EPA Substance Registry System: 6-bromo-8-methoxy-1,2,3,4-tetrahydroquinoline(1388056-45-8)

Safety Data

• Hazardous Substances Data: 1388056-45-8(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 190843-73-3 6,8-dibromo-1,2,3,4-tetrahydroquinoline 
• 635-46-1 1,2,3,4-tetrahydroisoquinoline 

Relevant articles and documents

Simple and convenient preparation of novel 6,8-disubstituted quinoline derivatives and their promising anticancer activities

A short and easy route is described for 6,8-disubstituted derivatives of quinoline and 1,2,3,4-tetrahydroquinoline from 6,8-dibromoquinolines 2 and 7 by various substitution reactions. While copper-promoted substitution of 6,8- dibromide 2 produced monomethoxides 3 and 4, a prolonged reaction time mainly afforded dimethoxide 6 instead of 5, whose aromatization with DDQ and substitution reaction of dibromide 7 with NaOMe in the presence of CuI also gave rise to dimethoxide 6. Several 6,8-disubstituted quinolines were obtained by treatment of 6,8-dibromoquinoline (7) with n-BuLi followed by trapping with an electrophile [Si(Me)3 Cl, S2 (Me)2; and DMF]. Furthermore, 7 was also converted to mono and dicyano derivatives. The anticancer activities of compounds 2, 7, 6, 12, 13, 15, and 16 against HeLa, HT29, and C6 tumor cell lines were tested, and 6,8-dibromo-1,2,3,4- tetrahydroquinoline (2) and 6,8-dimethoxyquinoline (6) showed significant anticancer activities against the tumor cell lines. TUeBITAK.