138828-25-8

Basic information

• Product Name: 2H-1-Benzopyran-2-carboxylic acid, 7-[3-[4-(chloroacetyl)-3-methoxy-2-propylphenoxy]propoxy]-3,4-dihydro- 8-propyl-, methyl ester
• CAS NO: 138828-25-8
• Molecular Formula: C29H37ClO7
• Molecular Weight: 533.062
• Mol File: 138828-25-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2H-1-Benzopyran-2-carboxylic acid, 7-[3-[4-(chloroacetyl)-3-methoxy-2-propylphenoxy]propoxy]-3,4-dihydro- 8-propyl-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-1-Benzopyran-2-carboxylic acid, 7-[3-[4-(chloroacetyl)-3-methoxy-2-propylphenoxy]propoxy]-3,4-dihydro- 8-propyl-, methyl ester(138828-25-8)
• EPA Substance Registry System: 2H-1-Benzopyran-2-carboxylic acid, 7-[3-[4-(chloroacetyl)-3-methoxy-2-propylphenoxy]propoxy]-3,4-dihydro- 8-propyl-, methyl ester(138828-25-8)

Safety Data

• Hazardous Substances Data: 138828-25-8(Hazardous Substances Data)

Downstream Products

• 138828-43-0 methyl 3,4-dihydro-7-<3-<4-(2,3-dihydro-2-thioxo-4-thiazolyl)-3-methoxy-2-propylphenoxy>propoxy>-8-propyl-2H-1-benzopyran-2-carboxylate 
• 138828-30-5 methyl 3,4-dihydro-7-<3-<3-methoxy-2-propyl-4-(thiazol-4-yl)phenoxy>propoxy>-8-propyl-2H-1-benzopyran-2-carboxylate 
• 138828-45-2 methyl 3,4-dihydro-7-<3-<3-methoxy-4-<2-(methylthio)-4-thiazolyl>-2-propylphenoxy>propoxy>-8-propyl-2H-1-benzopyran-2-carboxylate 
• 138828-41-8 methyl 3,4-dihydro-7-<3-<3-methoxy-4-(2-methoxy-4-thiazolyl)-2-propylphenoxy>propoxy>-8-propyl-2H-1-benzopyran-2-carboxylate 
• 138828-40-7 methyl 3,4-dihydro-7-<3-<3-methoxy-4-(1-oxo-2-thiocyanatoethyl)-2-propylphenoxy>propoxy>-8-propyl-2H-1-benzopyran-2-carboxylate 
• 138828-26-9 methyl 3,4-dihydro-7-<3-<3-methoxy-4-<2-<(phenylmethyl)thio>-1H-imidazol-4-yl>-2-propylphenoxy>propoxy>-8-propyl-2H-1-benzopyran-2-carboxylate 

Relevant articles and documents

Second-Generation Leukotriene B4 Receptor Antagonists Related to SC-41930: Heterocyclic Replacement of the Methyl Ketone Pharmacophore

Our previous reports have highlighted the first-generation leukotriene B4 (LTB4) receptor antagonist SC-41930 (7--3,4-dihydro-8-propyl-2H-1-benzopyran-2-carboxylic acid) which has potent oral, topical, and intracolonic activity in various animal models of inflammation.Extensive structure-activity relationship studies, in which series of heterocyclic replacements for the methyl ketone functional group of SC-41930 was explored, identified SC-50605 (7-propoxy>-3,4-dihydro-8-propyl-2H-1-benzopyran-2-carboxylic acid) as an optimized analog within a series of thiazoles.SC-50605 was found to be significantly more potent than SC-41930 in LTB4 receptor binding, chemotaxis, and degranulation assays.It also displayed very good activity in animal models of colitis and epidermal inflammation by oral, topical, intravenous, and intracolonic routes of administration.The resolved enantiomers of SC-50605 were obtained by chiral chromatography and both demonstrated good in vitro and in vivo activity.The (+)-isomer (SC-52798) is currently being evaluated as a potential clinical candidate for psoriasis and ulcerative colitis therapy.