138834-76-1

Basic information

• Product Name: 2-Pyridinecarboxylic acid, 5-[[[(phenylmethyl)sulfonyl]amino]carbonyl]-
• CAS NO: 138834-76-1
• Molecular Formula: C14H12N2O5S
• Molecular Weight: 320.326
• Mol File: 138834-76-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-Pyridinecarboxylic acid, 5-[[[(phenylmethyl)sulfonyl]amino]carbonyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyridinecarboxylic acid, 5-[[[(phenylmethyl)sulfonyl]amino]carbonyl]-(138834-76-1)
• EPA Substance Registry System: 2-Pyridinecarboxylic acid, 5-[[[(phenylmethyl)sulfonyl]amino]carbonyl]-(138834-76-1)

Safety Data

• Hazardous Substances Data: 138834-76-1(Hazardous Substances Data)

Upstream product

• 17874-76-9 6-(methoxycarbonyl)nicotinic acid 
• 4563-33-1 phenyl-methanesulfonic acid amide 
• 138834-66-9 methyl 5-[((benzylsulfonyl)amino)carbonyl]-pyridine-2-carboxylate 

Relevant articles and documents

Novel inhibitors of prolyl 4-hydroxylase

A series of 5-acyl sulfonamides derived from pyridine-2,5-dicarboxylic acid (15) has been prepared and several members of this series have been shown to be more potent, in vitro, as inhibitors of prolyl 4-hydroxylase than 15. Several chain-extended pyridinedicarboxylic acids have also been prepared and shown to be potent inhibitors of prolyl 4-hydroxylase. The structure- activity in both these series is discussed. The results indicate that the 5- carboxylic acid binding site, in the enzyme, can accept a carboxylic acid or an acyl sulfonamide equally well. This indicates a much greater degree of freedom in this distal carboxylic acid binding site than is predicted by the current theorical model of the active site.