1388859-69-5Relevant articles and documents
Facile conversion of CF3-containing propargylic alcohol derivatives via the corresponding allenes
Yamazaki, Takashi,Watanabe, Yohsuke,Yoshida, Nao,Kawasaki-Takasuka, Tomoko
supporting information; experimental part, p. 6665 - 6673 (2012/08/28)
Empirical information on the acidity of the propargylic proton from our previous work allowed us to develop novel synthetic transformations of readily available terminally trifluoromethylated propargylic alcohols 1 into the corresponding allenyl tosylates 3a, 1-tosyloxy- or 1-acyloxy-4,4,4- trifluorobutan-2-ones 4, and 2-(2,2,2-trifluoroethyl)prop-2-en-1-ones 5, which was enabled by such common bases as NaOH and tertiary amines for affecting ready abstraction of this proton.