138900-17-1

Basic information

• Product Name: 1H-Indole, 1-(4-fluorophenyl)-5-nitro-
• CAS NO: 138900-17-1
• Molecular Formula: C14H9FN2O2
• Molecular Weight: 256.236
• Mol File: 138900-17-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1H-Indole, 1-(4-fluorophenyl)-5-nitro-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole, 1-(4-fluorophenyl)-5-nitro-(138900-17-1)
• EPA Substance Registry System: 1H-Indole, 1-(4-fluorophenyl)-5-nitro-(138900-17-1)

Safety Data

• Hazardous Substances Data: 138900-17-1(Hazardous Substances Data)

Usage

Indole derivative

A class of compounds This compound belongs to the indole derivatives, which are known for their diverse biological activities and various applications in pharmaceuticals and organic synthesis.

Nitro group presence

Contributes to unique properties The presence of a nitro group (-NO2) in the chemical structure of the compound gives it specific reactivity and properties that can be exploited in chemical reactions and applications.

Fluorophenyl group presence

Influences potential applications The presence of a fluorophenyl group (a phenyl ring with a fluorine atom) in the structure adds to the compound's uniqueness and may influence its potential applications in pharmaceutical research and development.

Pharmaceutical research and development

Possible use 1H-Indole, 1-(4-fluorophenyl)-5-nitromay be used in the development of new drugs or the study of its biological activities to contribute to the understanding of its potential therapeutic effects.

Synthesis of other organic compounds

Possible use This compound can be used as a building block or intermediate in the synthesis of other organic compounds, allowing for the creation of new molecules with various applications.

Specific context dependency

Uses and effects The precise uses and effects of 1H-Indole, 1-(4-fluorophenyl)-5-nitrodepend on the specific context in which it is employed, such as the target organism, chemical reactions, or desired outcome.

Upstream product

• 352-34-1 4-fluoro-1-iodobenzene 
• 6146-52-7 5-nitroindole 

Relevant articles and documents

Structure Ligation Relationship of Amino Acids for the Amination Cross-Coupling Reactions

The structure ligation relationship (SLR) of amino acids (AAs) for the cross-coupling aminations was examined. While AA ligated C-N cross-couplings under Pd and Ni catalysis were minor or ineffective, the AA ligated Cu-catalyzed C-N cross-couplings were promising particularly with the use of l-methionine. The roles of -NH2, -CO2H, and -S- of l-methionine were investigated and found critical for their ligation efficiency. The finding was compatible with aromatic as well as aliphatic amines including tautomerizable N-heteroarenes.

Noncataleptogenic, centrally acting dopamine D-2 and serotonin 5-HT2 antagonists within a series of 3-substituted 1-(4-fluorophenyl)-1H-indoles

A series of 1-(4-fluorophenyl)-1H-indoles substituted at the 3-position with 1-piperazinyl, 1,2,3,6-tetrahydro-4-pyridinyl, and 4-piperidinyl was synthesized. Within all three subseries potent dopamine D-2 and serotonin 5- HT2 receptor affinity was found in ligand binding studies. Quipazine-induced head twitches in rats were inhibited by most derivatives as a measure of central 5-HT2 receptor antagonism. Piperazinyl and tetrahydropyridyl indoles were cataleptogenic, while piperidyl substituted indoles surprisingly were found to be noncataleptogenic or only weakly cataleptogenic. Noncataleptogenic piperidyl derivatives also failed to block dopaminergic- mediated stereotypies, that is methyl phenidate-induced gnawing behavior in mice. These profiles resemble that of the atypical neuroleptic clozapine. 1- Ethyl-2-imidazolidinone was found to be the optimal substituent of the basic nitrogen atom in order to avoid catalepsy. The atypical neuroleptic 1-[2-[4- [5-chloro-1-(4-fluorophenyl)-1H-indol-3-yl]-1-piperidinyl]ethyl]-2- imidazolidinone (sertindole, compound 14c) was selected for further development as a result of these structure/activity studies.