138906-72-6

Basic information

• Product Name: Cytidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]
• CAS NO: 138906-72-6
• Molecular Formula: C40H50N5O8P
• Molecular Weight: 759.839
• Mol File: 138906-72-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Cytidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite](CAS DataBase Reference)
• NIST Chemistry Reference: Cytidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite](138906-72-6)
• EPA Substance Registry System: Cytidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite](138906-72-6)

Safety Data

• Hazardous Substances Data: 138906-72-6(Hazardous Substances Data)

Upstream product

• 1228304-63-9 C₅₂H₆₄N₅O₉P 
• 199593-09-4 Diisopropyl-phosphoramidous acid (2R,3R,4R,5R)-5-(4-acetylamino-2-oxo-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-methoxy-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester 

Downstream Products

• 1228304-75-3 C₄₉H₆₇N₆O₈P 

Relevant articles and documents

Oligonucleotide synthesis involving deprotection of amidine-type protecting groups for nucleobases under acidic conditions

Amidine-type protecting groups, i.e., N,N-dimethylformamidine (dmf) and N,N-dibutylformamidine (dbf) groups, introduced into nucleobases were rapidly removed under mild acidic conditions using imidazolium triflate (IMT) or 1-hydroxybenztriazole (HOBt). This new deprotection strategy allowed a 2′-O-methyl-RNA derivative bearing a base-labile group to be efficiently synthesized using a silyl-type linker. It was also found that our new method could be applied to the synthesis of an unmodified RNA oligomer.