138908-56-2

Basic information

• Product Name: L-Tyrosine, N-[(1,1-dimethylethoxy)carbonyl]-3-methoxy-O-methyl-, methyl ester
• Synonyms: (L)-N-tert-butoxycarbonyl-3,4-dimethoxyphenylalanine methyl ester;methyl (S)-2-(tert-butoxycarbonylamino)-3-(3,4-dimethoxyphenyl)propanoate;(S)-2-tert-butoxycarbonylamino-3-(3,4-dimethoxyphenyl)propionic acid methyl ester
• CAS NO: 138908-56-2
• Molecular Formula: C17H25NO6
• Molecular Weight: 339.389
• Mol File: 138908-56-2.mol
• Article Data: 13

Chemical Properties

• Melting Point: 77-78 °C(Solv: heptane (142-82-5); ethyl acetate (141-78-6))
• Boiling Point: 463.8±45.0 °C(Predicted)
• Density: 1.123±0.06 g/cm3(Predicted)
• CAS DataBase Reference: L-Tyrosine, N-[(1,1-dimethylethoxy)carbonyl]-3-methoxy-O-methyl-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Tyrosine, N-[(1,1-dimethylethoxy)carbonyl]-3-methoxy-O-methyl-, methyl ester(138908-56-2)
• EPA Substance Registry System: L-Tyrosine, N-[(1,1-dimethylethoxy)carbonyl]-3-methoxy-O-methyl-, methyl ester(138908-56-2)

Safety Data

• Hazardous Substances Data: 138908-56-2(Hazardous Substances Data)

Usage

Description

L-Tyrosine, N-[(1,1-dimethylethoxy)carbonyl]-3-methoxy-O-methyl-methyl ester is a chemical compound derived from L-Tyrosine, an amino acid that serves as a precursor to various neurotransmitters and hormones. This specific compound is characterized by its unique structural features, including a dimethylethoxycarbonyl group, a methoxy group, and a methyl ester group. These modifications to the L-Tyrosine structure may enhance its properties and potential applications in various fields.

Uses

Used in Pharmaceutical Industry:
L-Tyrosine, N-[(1,1-dimethylethoxy)carbonyl]-3-methoxy-O-methyl-methyl ester is used as an intermediate in the synthesis of N-Methyl-L-DOPA (M303825) for pharmaceutical applications. N-Methyl-L-DOPA is a methylated form of L-DOPA, which is known for its role in the treatment of Parkinson's disease. The compound acts as a potential alternative substrate or competitive inhibitor of tyrosinase, an enzyme involved in the production of melanin and other biological processes.
Used in Research and Development:
L-Tyrosine, N-[(1,1-dimethylethoxy)carbonyl]-3-methoxy-O-methyl-,
methyl ester may also be utilized in research and development for the study of tyrosinase and its role in various biological processes. By understanding the interactions between L-Tyrosine, N-[(1,1-dimethylethoxy)carbonyl]-3-methoxy-O-methyl-methyl ester and tyrosinase, researchers can gain insights into the development of new therapeutic strategies for conditions related to tyrosinase dysregulation.

Upstream product

• 37169-36-1 methyl (S)-2-(tert-butoxycarbonylamino)-3-(3,4-dihydroxyphenyl)propanoate 
• 77-78-1 dimethyl sulfate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 7101-51-1 L-DOPA methyl ester 
• 59-92-7 levodopa 
• 32161-30-1 (S)-3,4-dimethoxyphenylalanine 
• 74-88-4 methyl iodide 
• 30033-24-0 (2S)-3-(3,4-dihydroxyphenyl)-2-[(tert-butoxy)carbonylamino]propanoic acid 
• 127095-97-0 (2S)-2-[(tert-butoxycarbonyl)amino]-3-(3,4-dimethoxyphenyl)propanoic acid 

Downstream Products

• 190517-66-9 methyl (S)-2-amino-3-(2-bromo-4,5-dimethoxyphenyl)propanoate 
• 211619-94-2 methyl (S)-3-(2-bromo-4,5-dimethoxyphenyl)-2-((tert-butoxycarbonyl)amino)propanoate 

Relevant articles and documents

Racemic and diastereoselective synthesis of aryl and heteroaryl tetrahydroisoquinolines via the Pictet-Spengler reaction

New tetrahydroisoquinolines were synthesized by the Pictet-Spengler reaction. Influence of a wide range of aryl and heteroaryl aldehydes, was investigated in the cyclization step with 3,4-dimethoxyphenylethylamine 1, L-DOPA 2 and L-3,4-dimethoxyphenylalan

Polyphenol compound containing tetrahydropapaverine-3-methyl carboxylate, preparation method and applications thereof

The invention discloses a polyphenol compound containing tetrahydropapaverine-3-methyl carboxylate, a preparation method and applications thereof, wherein the polyphenol compound has a structure represented by a formula I, and R is hydrogen, halogen, C1-8 alkyl, C1-8 cycloalkyl, C1-8 halogenated alkyl, C1-8 alkoxy, C1-8 halogenated alkoxy, C2-4 alkenyl, phenyl, halogenated phenyl, nitrophenyl, C1-4 alkyl substituted phenyl, C1-4 halogenated alkyl substituted phenyl, naphthalene or acylamino. According to the invention, the polyphenol compound is novel in structure and generally has relativelygood inhibitory activity on influenza A virus H1N1, and the inhibitory effect of most compounds is superior to the inhibitory effect of a positive control Perimivir, so that the results show that thecompound has obvious inhibiting effect on influenza A virus, can be prepared into anti-influenza A virus medicine to be applied, has good application prospects in prevention and treatment of influenzavirus infection, and expands the application of tetrahydropapaverine structures as anti-influenza virus medicine.

An Au(I)-catalysed allenamide cyclisation giving access to an α-vinyl-substituted tetrahydroisoquinoline building block

An Au(I)-catalysed intramolecular hydroarylation of an enantiopure allenamide has been achieved and has given access to a key α-vinyl- substititued tetrahydroisoquinoline. Additionally this has been accomplished in very high yield and high diastereoselectivity. Georg Thieme Verlag Stuttgart · New York.