138969-09-2

Basic information

• Product Name: 1H-Benzimidazole-5-carboxylic acid, 2-(4-methoxyphenyl)-, methyl ester
• CAS NO: 138969-09-2
• Molecular Formula: C16H14N2O3
• Molecular Weight: 282.299
• Mol File: 138969-09-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1H-Benzimidazole-5-carboxylic acid, 2-(4-methoxyphenyl)-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Benzimidazole-5-carboxylic acid, 2-(4-methoxyphenyl)-, methyl ester(138969-09-2)
• EPA Substance Registry System: 1H-Benzimidazole-5-carboxylic acid, 2-(4-methoxyphenyl)-, methyl ester(138969-09-2)

Safety Data

• Hazardous Substances Data: 138969-09-2(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 123-11-5 4-methoxy-benzaldehyde 
• 619-05-6 3,4-diaminobenzoic acid 
• 528-45-0 3,4-dinitrobenzoic acid 
• 36692-49-6 Methyl 3,4-diaminobenzoate 
• 22907-68-2 3,4-dinitrobenzoic acid methyl ester 
• 2393-23-9 4-methoxy-benzylamine 

Downstream Products

• 138969-08-1 8-[2-(4-Methoxy-phenyl)-3H-benzoimidazol-5-yl]-2-(4-methyl-piperazin-1-yl)-9H-purine 
• 126824-22-4 2-(4-methoxyphenyl)-1H-benzo[d]imidazole-6-carbaldehyde 
• 126824-21-3 5-(Hydroxymethyl)-2-(4-methoxyphenyl)-1H-benzimidazole 

Relevant articles and documents

Synthesis, anticancer evaluation and molecular docking studies of new benzimidazole- 1,3,4-oxadiazole derivatives as human topoisomerase types I poison

In this study, some benzimidazole-oxadiazole derivatives were synthesised and tested for their in vitro anticancer activities on five cancer cell lines, including HeLa, MCF7, A549, HepG2 and C6. Their structures were elucidated by IR, 1H-NMR,

Synthesis and biological evaluation of benzimidazole-oxindole conjugates as microtubule-targeting agents

A series of benzimidazole-oxindole conjugates were synthesized and evaluated for their cytotoxic activity. The cytotoxicity assay results suggest that conjugates 5c and 5p exhibit promising cytotoxicity against human breast cancer cell line (MCF-7). The Cell cycle analysis revealed that these conjugates induced cell cycle arrest at G2/M phase in MCF-7 cells. The tubulin polymerization assay results suggested that these conjugates inhibit tubulin polymerization with IC50 values 1.12 and 1.59 μM respectively. Immunofluorescence analysis also suggested that these conjugates effectively inhibited the microtubule assembly in MCF-7 cells. Further, molecular docking studies indicated that these conjugates 5c and 5p interact and binds efficiently with the tubulin protein. By and large, the results demonstrated that these benzimidazole-oxindole conjugates possess cytotoxic property by inhibiting the tubulin polymerization.

SYNTHESIS AND DNA BINDING PROPERTIES OF A PURINE ANALOGUE OF BISBENZIMIDE

The synthesis of a purine containing analogue (1) of bisbenzimide (2) and its DNA binding properties are described.Analogue 1 is found to have increased tolerance for binding to GC sites implying the formation of the new hydrogen bonds between guanine-2-N