138996-44-8Relevant articles and documents
Substituent effect in reaction of dicyclohexylcarbodiimide with substituted benzoic acids
Slebioda, Marek
, p. 7829 - 7834 (1995)
A curved Hammett relationship was observed for the reaction of substituted benzoic acids with dicyclohexylcarbodiimide in buffered solution. The reaction is promoted by electron-withdrawing substituents because of larger concentration of the acid anion pr
N-heterocyclic carbene catalyzed oxidative coupling of aldehydes with carbodiimides under aerobic conditions: Efficient synthesis of N-acylureas
Soeta, Takahiro,Tabatake, Yuhta,Fujinami, Shuhei,Ukaji, Yutaka
supporting information, p. 2088 - 2091 (2013/06/05)
The oxidative coupling reaction of aldehydes with N,N′-disubstituted carbodiimides catalyzed by N-heterocyclic carbenes under aerobic conditions has been achieved. This reaction gives the corresponding N-acylurea derivatives in good to high yields. Various kinds of aldehydes including aliphatic ones and carbodiimides are applicable to this reaction.
2-thiophenecarbohydrazides: A novel efficient method for the synthesis of 2-thiophenecarbohydrazide
Elshaarawy, Reda F.M.,Janiakb, Christoph
experimental part, p. 1202 - 1208 (2012/03/09)
Hydrazinolysis of carboxylic acid esters in alcoholic solutions is the standard method for preparing carbohydrazides (carboxylic hydrazides). Here we report an efficient process, involving the reaction of activated esters or amides with hydrazine, for the preparation of thiophenecarbohydrazides in yields larger than 90% and high purity. With this new method, a series of heteroaryl-, aryl-, or aralkyl- substituted carbohydrazides were synthesized and characterized. The X-ray crystal structure of 2-thiophenecarbohydrazide (thiophene-2-carboxylic hydrazide, 2-thenoyl-hydrazine) has revealed that it crystallizes in the monoclinic system, space group P21/c, with cell parameters of a = 6.1202(2), b = 8.3907(3), c = 12.5332(5) A, β = 98.6577(11)?, Z = 4, R(F) = 0.0455 and wR(F2) = 0.1805, T = 293 K.