139004-93-6

Basic information

• Product Name: (R)-PIPERIDIN-2-YLMETHYL-CARBAMIC ACID TERT-BUTYL ESTER
• Synonyms: (S)-tert-butyl piperidin-2-ylmethylcarbamate hydrochloride;S-2-BOC-AMINOMETHYL-PIPERIDINE-HCl;(S)-tert-Butyl (piperidin-2-ylMethyl)carbaMate;CarbaMic acid, N-[(2S)-2-piperidinylMethyl]-, 1,1-diMethylethyl ester;(S)-2-[[(tert-Butoxycarbonyl)amino]methyl]piperidine;tert-Butyl ((2S)-piperidin-2-ylmethyl)carbamate;tert-butyl N-[(2S)-piperidin-2-ylmethyl]carbamate;tert-butyl (S)-(piperidin-2-ylmethyl)carbamate
• CAS NO: 139004-93-6
• Molecular Formula: C₁₁H₂₂N₂O₂
• Molecular Weight: 214.31
• Mol File: 139004-93-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 287.9°C at 760 mmHg
• Flash Point: 127.9°C
• Appearance: /
• Density: 1.01g/cm³
• Vapor Pressure: 0.00242mmHg at 25°C
• Refractive Index: 1.485
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (R)-PIPERIDIN-2-YLMETHYL-CARBAMIC ACID TERT-BUTYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-PIPERIDIN-2-YLMETHYL-CARBAMIC ACID TERT-BUTYL ESTER(139004-93-6)
• EPA Substance Registry System: (R)-PIPERIDIN-2-YLMETHYL-CARBAMIC ACID TERT-BUTYL ESTER(139004-93-6)

Safety Data

• Hazardous Substances Data: 139004-93-6(Hazardous Substances Data)

Usage

Uses

Chiral building block developed using Liverpool ChiroChem-patented technology.

InChI:InChI=1/C11H22N2O2/c1-11(2,3)15-10(14)13(4)9-7-5-6-8-12-9/h9,12H,5-8H2,1-4H3

Upstream product

• 248914-23-0 tert-butyl ({(2S)-1-[(1R)-2-hydroxy-1-phenylethyl]piperidin-2-yl}methyl)carbamate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 153918-98-0 (2R)-2-<(2S)-2-(aminomethyl)piperidin-1-yl>-2-phenylethanol 
• 18650-39-0 (S)-methyl pipecolinate hydrochloride 
• 19889-77-1 (2S)-2-piperidinecarboxamide 
• 139004-92-5 (S)-N-benzyl-2-aminomethylpiperidine 
• 139004-91-4 (S)-1-Benzyl-piperidine-2-carboxylic acid amide 
• 3105-95-1 pipecolinic acid 

Downstream Products

• 248914-24-1 tert-butyl {[(2S)-1-(chloroacetyl)piperidin-2-yl]methyl}carbamate 
• 179605-63-1 (S)-octahydro-2H-pyrido[1,2-a]pyrazine 
• 248914-28-5 (S)-4-oxooctahydro-2H-pyrido[1,2-a]pyrazine 
• 1083282-96-5 (S)-{1-[2-cyclopropyl-5-(2-fluoro-phenyl)-thiazole-4-carbonyl]-piperidin-2-ylmethyl}-carbamic acid tert-butyl ester 
• 380899-36-5 tert-butyl [((2S)-1-{[5-(4-fluorophenyl)-2-methyl-1,3-thiazol-4-yl]carbonyl}piperidin-2-yl)methyl]carbamate 
• 1137129-14-6 (S)-{1-[2-bromo-5-(4-fluoro-phenyl)-thiazole-4-carbonyl]-piperidin-2-ylmethyl}-carbamic acid tert-butyl ester 
• 879609-50-4 (S)-N-((1-isobutylpiperidin-2-yl)methyl)-2-methylpropan-1-amine 
• 380899-51-4 C₁₇H₂₀FN₃OS 
• 1083281-00-8 (S)-N-{1-[2-cyclopropyl-5-(2-fluoro-phenyl)-thiazole-4-carbonyl]-piperidin-2-ylmethyl}-3-methyl-benzamide 
• 1083283-00-4 (S)-(2-aminomethyl-piperidin-1-yl)-[2-cyclopropyl-5-(2-fluoro-phenyl)-thiazol-4-yl]-methanone hydrochloride 

Relevant articles and documents

PYRIDAZINONE DERIVATIVES AS PARP INHIBITORS

The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts or tautomers thereof which are inhibitors of poly(ADP-ribose)polymerase (PARP) and thus useful for the treatment of cancer, inflammatory diseases, reperfusion injuries, ischaemic conditions, stroke, renal failure, cardiovascular diseases, vascular diseases other than cardiovascular diseases, diabetes mellitus, neurodegenerative diseases, retroviral infections, retinaldamage, skin senescence and UV-induced skin damage, and as chemo-or radiosensitizers for cancer treatment.

Asymmetric synthesis of octahydro-2H-pyrido[1,2-a]-pyrazines

A series of optically pure octahydro-2H-pyrido[1,2-a]pyrazines has been prepared from (-)-2-cyano-6-phenyloxazolopiperidine (4). 2H-Pyrido[1,2- a]pyrazin-3-(4H)-one (7) and octahydro-2H-pyrido[1,2-a]pyrazine (14) were obtained from diamino alcohol (5) by