139021-94-6

Basic information

• Product Name: 1,3-Dithiane, 2-(4-chlorophenyl)-2-phenyl-
• CAS NO: 139021-94-6
• Molecular Formula: C16H15ClS2
• Molecular Weight: 306.88
• Mol File: 139021-94-6.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 1,3-Dithiane, 2-(4-chlorophenyl)-2-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Dithiane, 2-(4-chlorophenyl)-2-phenyl-(139021-94-6)
• EPA Substance Registry System: 1,3-Dithiane, 2-(4-chlorophenyl)-2-phenyl-(139021-94-6)

Safety Data

• Hazardous Substances Data: 139021-94-6(Hazardous Substances Data)

Upstream product

• 106-39-8 bromochlorobenzene 
• 5425-44-5 2-Phenyl-[1,3]dithiane 
• 109-80-8 1.3-propanedithiol 
• 134-85-0 4-chlorobenzophenone 

Downstream Products

• 831-81-2 4-chlorophenyl(phenyl)methane 
• 134-85-0 4-chlorobenzophenone 
• 109-80-8 1.3-propanedithiol 

Relevant articles and documents

Super electron donor-mediated reductive desulfurization reactions

The desulfurization of thioacetals and thioethers by a pyridine-derived electron donor is described. This methodology provides efficient access to the reduced products in high yields and does not require the use of transition-metals, elemental alkali-metals, or hydrogen atom donors.

Reversed-polarity synthesis of diaryl ketones through palladium-catalyzed direct arylation of 2-Aryl-1,3-dithianes

An umpolung approach to the synthesis of diaryl ketones has been developed based on in situ generation of acyl anion equivalents and their catalytic arylation. This method entails the base-promoted, palladium-catalyzed direct C-H arylation of 2- aryl-1,3-dithianes with aryl bromides. Use of ( SiMe3)2 (M=Li, Na) base results in reversible deprotonation of the weakly acidic dithiane. In the presence of a Pd(NiXantphos)-based catalyst and aryl bromide, cross-coupling of the metallated 2-aryl- 1,3-dithiane takes place under mild conditions (2 h at rt) with yields as high as 96%. The resulting 2,2- diaryl-1,3-dithianes were converted into diaryl ketones by either molecular iodine, N-bromo succinimide (NBS) or Selectfluor in the presence of water. The dithiane arylation/hydrolysis can be performed in a one-pot procedure to yield a variety of diaryl ketones in good to excellent yields. This method is suitable for rapid and large-scale synthesis of diaryl ketones. A one-pot preparation of anti-cholesterol drug fenofibrate (TriCor) has been achieved on 10.0 mmol scale in 86% yield.

Silica-supported phosphorus pentoxide: A reusable catalyst for S,S-acetalization of carbonyl groups under ambient conditions

Phosphorus pentoxide supported on silica gel (P2O 5/SiO2) efficiently acts as a highly active and reusable catalyst for cyclic and non-cyclic S,S-acetalization of a variety of carbonyl compounds under mild, solvent-free an