13906-89-3Relevant articles and documents
Copper-catalyzed ring-opening reactions of alkyl aziridines with b2 pin2: Experimental and computational studies
Boldrini, Cosimo,Comparini, Lucrezia Margherita,Di Bussolo, Valeria,Di Pietro, Sebastiano,Favero, Lucilla,Menichetti, Andrea,Pineschi, Mauro
supporting information, (2021/12/17)
The possibility to form new C–B bonds with aziridines using diboron derivatives con-tinues to be a particularly challenging field in view of the direct preparation of functionalized β-aminoboronates, which are important compounds in drug discovery, being a bioisostere of β-aminoacids. We now report experimental and computational data that allows the individua-tion of the structural requisites and of reaction conditions necessary to open alkyl aziridines using bis(pinacolate)diboron (B2 pin2 ) in a regioselective nucleophilic addition reaction under copper catalysis.
Scalable synthesis of N -acylaziridines from N -tosylaziridines
Rubin, Heather,Cockrell, Jennifer,Morgan, Jeremy B.
, p. 8865 - 8871 (2013/09/24)
N-Acylaziridines are important starting materials for the synthesis of chiral amine derivatives. The traditional methods for producing these activated aziridines have significant drawbacks. The gram scale synthesis of N-acylaziridines by deprotection of N
Phosphine-catalyzed heine reaction
Martin, Allen,Casto, Kathleen,Morris, William,Morgan, Jeremy B.
, p. 5444 - 5447 (2011/12/05)
Aziridines are important synthetic intermediates which readily undergo ring-opening reactions. It is demonstrated that electron-rich phosphines are efficient catalysts for the regioselective rearrangement of N-acylaziridines to oxazolines. The reactions o
