13908-30-0

Basic information

• Product Name: 1-(2-chloroethyl)-3-[(3alpha,5alpha)-cholestan-3-yl]urea
• CAS NO: 13908-30-0
• Molecular Formula: C₃₀H₅₃ClN₂O
• Molecular Weight: 493.2076
• Mol File: 13908-30-0.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 599.5°C at 760 mmHg
• Flash Point: 316.4°C
• Density: 1.04g/cm³
• Vapor Pressure: 2.47E-14mmHg at 25°C
• Refractive Index: 1.524
• CAS DataBase Reference: 1-(2-chloroethyl)-3-[(3alpha,5alpha)-cholestan-3-yl]urea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-chloroethyl)-3-[(3alpha,5alpha)-cholestan-3-yl]urea(13908-30-0)
• EPA Substance Registry System: 1-(2-chloroethyl)-3-[(3alpha,5alpha)-cholestan-3-yl]urea(13908-30-0)

Safety Data

• Hazardous Substances Data: 13908-30-0(Hazardous Substances Data)

Usage

Description

1-(2-chloroethyl)-3-[(3alpha,5alpha)-cholestan-3-yl]urea, commonly known as chlormethine, is a nitrogen mustard alkylating agent derived from the chemical class of alkylating agents. It is characterized by its potent anticancer properties and its ability to interfere with the growth and spread of cancer cells within the body. Chlormethine is also recognized as a powerful vesicant, which means it can cause severe skin burns and tissue damage upon contact, necessitating extreme caution in its handling and administration.

Uses

Used in Cancer Treatment:
Chlormethine is utilized as an anticancer agent, specifically for the treatment of various types of cancer, including Hodgkin's disease and non-Hodgkin lymphomas. It functions by disrupting the cellular processes that enable cancer cells to grow and proliferate, thereby inhibiting tumor progression and spread.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, chlormethine is employed as a component in combination chemotherapy regimens. Its inclusion in these multi-drug treatments enhances the overall efficacy of the regimen, providing a more comprehensive approach to cancer treatment.
Used in Medical Research:
Chlormethine is also used in medical research as a model compound for studying the mechanisms of action and potential side effects of alkylating agents. This research contributes to the development of new and improved cancer treatments, as well as a better understanding of the biological processes involved in cancer cell growth and proliferation.
Despite its potential for serious side effects and toxicity, chlormethine remains an important and effective treatment option for certain types of cancer, particularly when used in combination with other therapies. Its administration is typically carried out through intravenous infusion or topical application as a gel, ensuring targeted delivery to the affected areas while minimizing systemic exposure and potential side effects.