139102-34-4

Basic information

• Product Name: METHYL 4-BROMO-2-METHOXYBENZOATE 98
• Synonyms: METHYL 4-BROMO-2-METHOXYBENZOATE 98;METHYL 4-BROMO-2-METHOXYBENZOATE, PURISS;Methyl 4-bromo-2-methoxybenzoate 98%;4-BROMO-2-METHOXYBENZOATE;2-methoxy-4-bromobenzoate
• CAS NO: 139102-34-4
• Molecular Formula: C₉H₉BrO₃
• Molecular Weight: 245.071
• Product Categories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Acids & Esters;Anisoles, Alkyloxy Compounds & Phenylacetates;Bromine Compounds;C8 to C9;Carbonyl Compounds;Esters
• Mol File: 139102-34-4.mol
• Article Data: 14

Chemical Properties

• Melting Point: 33 °C(lit.)
• Boiling Point: 52 °C0.01 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: /low-melting solid
• Density: 1.463 g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.538
• Storage Temp.: Room temperature.
• Solubility: soluble in Toluene
• CAS DataBase Reference: METHYL 4-BROMO-2-METHOXYBENZOATE 98(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 4-BROMO-2-METHOXYBENZOATE 98(139102-34-4)
• EPA Substance Registry System: METHYL 4-BROMO-2-METHOXYBENZOATE 98(139102-34-4)

Safety Data

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• PackingGroup: III
• Hazardous Substances Data: 139102-34-4(Hazardous Substances Data)

Usage

Chemical Properties

White powder

InChI:InChI=1/C9H9BrO3/c1-12-8-5-6(10)3-4-7(8)9(11)13-2/h3-5H,1-2H3

Upstream product

• 1666-28-0 4-bromosalicylic acid 
• 74-88-4 methyl iodide 
• 72135-36-5 4-bromo-2-methoxybenzoic acid 
• 22717-56-2 4-bromo-2-Hydroxybenzoic Acid Methylester 
• 77-78-1 dimethyl sulfate 
• 67-56-1 methanol 

Downstream Products

• 17102-63-5 (4-bromo-2-methoxyphenyl)methanol 
• 693257-37-3 3-methoxy-4'-nitro-biphenyl-4-carboxylic acid (3-hydroxy-phenyl)-amide 
• 693257-38-4 3-hydroxy-4'-nitro-biphenyl-4-carboxylic acid (3-hydroxy-phenyl)-amide 
• 43192-33-2 4-bromo-2-methoxybenzaldehyde 
• 99641-62-0 4-Bromo-2-methoxy-1-((E)-2-nitro-propenyl)-benzene 
• 99632-51-6 (+/-)-1-(4-bromo-2-methoxyphenyl)-2-aminopropane 
• 139102-26-4 2-(4-bromo-2-methoxyphenyl)aminoethane 
• 72135-36-5 4-bromo-2-methoxybenzoic acid 
• 603122-40-3 methyl 2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate 
• 908247-92-7 methyl 2-methoxy-4-(3,3-dimethylbut-1-ynyl)benzoate 
• 1045771-51-4 2-methoxy-4-[2-(trimethylsilanyl)ethanesulfonylamino]benzoic acid methyl ester 
• 812667-44-0 4-bromo-2-methoxybenzamide 
• 1154414-98-8 methyl 2-methoxy-4-morpholinobenzoate 
• 1154414-74-0 C₁₄H₁₉NO₄ 

Relevant articles and documents

Highly selective electroreductive linear dimerization of electron-deficient vinylarenes

A direct electroreductive dimerization of electron-deficient vinylarenes for the synthesis of 1,4-diarylbutane has been developed using a simple undivided cell with inexpensive carbon electrodes at room temperature. The control and deuterium-labeling experiments of electroreductive dimerization suggest that the hydrogen source comes from the solvent CH3CN. This protocol provides a mild and efficient route for the construction of C–C bond in moderate to good yields with high regioselectivity and broad substrate scope.

Design, synthesis, and preliminary biological evaluation of 3′,4′,5′-trimethoxy flavonoid salicylate derivatives as potential anti-tumor agents

According to the pharmacophore combination principle, a set of new 3′,4′,5′-trimethoxy flavonoid salicylate derivatives were designed, synthesized, and evaluated for biological activity. The cytotoxicity evaluation revealed that compound 10v exhibited higher potency than 5-Fu against HCT-116 cells. Preliminary biological activity studies showed that compound 10v could inhibit the colony formation and migration of HCT-116 cells. Besides, the Hoechst 33258 staining assay and flow cytometry revealed that treatment with compound 10v induced the apoptosis of HCT-116 cells in a concentration-dependent manner, while it had no effect on their cell cycle. The WB analysis suggested that HIF-1α, tubulin, HK-2, and PFK might be the potential pharmacophore targets of compound 10v. Tubulin was a potential drug target for compound 10v, which was explained by analyzing the crystal structure of compound 10v complexed with tubulin. These results indicated that compound 10v might be a promising anti-tumor agent candidate, deserving further optimization and evaluation.

METHOD FOR THE PREPARATION OF (4S)-4-(4-CYANO-2-METHOXYPHENYL)-5-ETHOXY-2,8-DIMETHYL-1,4-DIHYDRO-1-6-NAPHTHYRIDINE-3-CARBOXAMIDE AND THE PURIFICATION THEREOF FOR USE AS AN ACTIVE PHARMACEUTICAL INGREDIENT

The present invention relates to a novel and improved process for preparing (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide of the formula (I)