1391054-29-7Relevant articles and documents
Synthesis and biological evaluation of novel anticancer bivalent colchicine-tubulizine hybrids
Malysheva, Yulia B.,Combes, Sebastien,Allegro, Diane,Peyrot, Vincent,Knochel, Paul,Gavryushin, Andrei E.,Fedorov, Alexey Yu.
, p. 4271 - 4278 (2012/08/28)
A series of novel antimitotic hybrids were synthesized in good yields by linking of azide-containing colchicine congeners with acetylene-substituted tubulizine-type derivatives using copper-mediated 1,3-dipolar cycloaddition. Obtained compounds exhibit go