13916-99-9

Basic information

• Product Name: 1-CYANO-4-FLUORONAPHTHALENE
• Synonyms: 1-CYANO-4-FLUORONAPHTHALENE;BUTTPARK 11\09-58;4-Fluoronaphthalene-1-carbonitrile, 97%;4-Fluoro-1-naphthonitrile 97%;4-Fluoronaphthalene-1-carbonitrile, 1-Cyano-4-fluoronaphthalene;1-Naphthalenecarbonitrile, 4-fluoro-;4-Fluoro-1-naphthonitrile
• CAS NO: 13916-99-9
• Molecular Formula: C₁₁H₆FN
• Molecular Weight: 171.17
• Mol File: 13916-99-9.mol
• Article Data: 3

Chemical Properties

• Melting Point: 89-91°C
• Boiling Point: 314.9 °C at 760 mmHg
• Flash Point: 156.3 °C
• Appearance: /
• Density: 1.22g/cm³
• Vapor Pressure: 0.000452mmHg at 25°C
• Refractive Index: 1.621
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1-CYANO-4-FLUORONAPHTHALENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-CYANO-4-FLUORONAPHTHALENE(13916-99-9)
• EPA Substance Registry System: 1-CYANO-4-FLUORONAPHTHALENE(13916-99-9)

Safety Data

• Hazard Codes: T
• Statements: 20/21/22
• Safety Statements: 26-36/37/39
• RIDADR: 3439
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 13916-99-9(Hazardous Substances Data)

Usage

General Description

1-Cyano-4-fluoronaphthalene is a chemical compound with the formula C_12H_7N. It is a naphthalene derivative with a cyano group (-CN) and a fluorine atom attached to the naphthalene ring. 1-CYANO-4-FLUORONAPHTHALENE is a yellowish solid and is commonly used as a building block in the synthesis of various organic compounds. It has potential applications in the pharmaceutical industry, as a precursor for the production of dyes and pigments, and as a fluorescent probe in biological imaging. 1-Cyano-4-fluoronaphthalene is also used in research and development processes to create new materials and substances with specific properties. However, it is important to handle this chemical with care due to its potentially hazardous properties.

InChI:InChI=1/C11H6FN/c12-11-6-5-8(7-13)9-3-1-2-4-10(9)11/h1-6H

Upstream product

• 341-41-3 1-bromo-4-fluoronaphthalene 
• 544-92-3 copper(I) cyanide 
• 14906-59-3 4-cyanopyridine N-oxide 

Downstream Products

• 573-03-5 4-fluoro-1-naphthoic acid 
• 870889-35-3 4-(8-azabicyclo[3.2.1]oct-8-yl)naphthalene-1-carbonitrile 
• 870888-46-3 4-(3-hydroxy-8-azabicyclo[3.2.1]oct-8-yl)naphthalene-1-carbonitrile 
• 1202577-02-3 4-(4-formylphenoxy)-1-naphthonitrile 
• 1202575-39-0 3-{4-[(4-cyano-1-naphthyl)oxy]phenyl}-3-ethoxy propionic acid 
• 1202577-03-4 Ethyl 3-{4-[(4-cyano-1-naphthyl)oxy]phenyl}-3-hydroxypropionate 
• 1202577-04-5 ethyl 3-{4-[(4-cyano-1-naphthyl)oxy]phenyl}-3-ethoxy propionate 
• 1055361-84-6 4-(4-formyl-2-methoxyphenoxy)naphthalene-1-carbonitrile 
• 1264751-92-9 4-(2-methoxy-4-{(Z)-[4-(methylamino)-2-oxo-1,3-thiazol-5(2H)-ylidene]methyl}phenoxy)naphthalene-1-carbonitrile 
• 1264754-24-6 4-(4-{hydroxy[4-(methylamino)-2-oxo-2,5-dihydro-1,3-thiazol-5-yl]methyl}-2-methoxyphenoxy)naphthalene-1-carbonitrile 
• 1264751-93-0 4-{4-[(Z)-(4-amino-2-oxo-1,3-thiazol-5(2H)-ylidene)methyl]-2-methoxyphenoxy}naphthalene-1-carbonitrile 
• 1264751-99-6 4-(4-{(Z)-[4-{[2-(diethylamino)ethyl]amino}-2-oxo-1,3-thiazol-5(2H)-ylidene]methyl}-2-methoxyphenoxy)naphthalene-1-carbonitrile 
• 1264751-34-9 4-{4-[(Z)-(1-ethyl-5-imino-2-oxoimidazolidin-4-ylidene)methyl]-2-methoxyphenoxy}naphthalene-1-carbonitrile 
• 1264753-55-0 4-{4-[(Z)-(1-ethyl-5-imino-3-methyl-2-oxoimidazolidin-4-ylidene)methyl]-2-methoxyphenoxy}naphthalene-1-carbonitrile 

Relevant articles and documents

Design, synthesis and biological evaluation of aminobenzyloxyarylamide derivatives as selective κ opioid receptor antagonists

Opioid receptors play an important role in both behavioral and mood functions. Based on the structural modification of LY2456302, a series of aminobenzyloxyarylamide derivatives were designed and synthesized as κ opioid receptor antagonists. The κ opioid receptor binding ability of these compounds were evaluated with opioid receptors binding assays. Compounds 1a-d showed high affinity for κ opioid receptor. Especially for compound 1c, exhibited a significant Kivalue of 15.7?nM for κ opioid receptor binding and a higher selectivity over μ and δ opioid receptors compared to (±)LY2456302. In addition, compound 1c also showed potent κ antagonist activity with κ IC50?=?9.32?nM in [35S]GTP-γ-S functional assay. The potential use of the representative compounds as antidepressants was also investigated. The most potent compound 1c not only exhibited potent antidepressant activity in the mice forced swimming test, but also displayed the effect of anti-anxiety in the elevated plus-maze test.