1391948-49-4

Basic information

• Product Name: N'-(1-(2,4-dibromophenyl)ethylidene)-4-(trifluoromethyl)-1,2,3-thiadiazole-5-carbohydrazide
• Synonyms: N'-(1-(2,4-dibromophenyl)ethylidene)-4-(trifluoromethyl)-1,2,3-thiadiazole-5-carbohydrazide
• CAS NO: 1391948-49-4
• Molecular Weight: 472.083
• Mol File: 1391948-49-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N'-(1-(2,4-dibromophenyl)ethylidene)-4-(trifluoromethyl)-1,2,3-thiadiazole-5-carbohydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: N'-(1-(2,4-dibromophenyl)ethylidene)-4-(trifluoromethyl)-1,2,3-thiadiazole-5-carbohydrazide(1391948-49-4)
• EPA Substance Registry System: N'-(1-(2,4-dibromophenyl)ethylidene)-4-(trifluoromethyl)-1,2,3-thiadiazole-5-carbohydrazide(1391948-49-4)

Safety Data

• Hazardous Substances Data: 1391948-49-4(Hazardous Substances Data)

Upstream product

• 33243-33-3 2,4-dibromoacetophenone 
• 1391948-36-9 4-(trifluoromethyl)-1,2,3-thiadiazole-5-carbohydrazide 

Relevant articles and documents

Synthesis, antimicrobial and cytotoxic activities of novel 4-trifluoromethyl-(1,2,3)-thiadiazolo-5-carboxylic acid hydrazide Schiff's bases

A series of novel 1,2,3-thiadiazolo-5-carboxylic acid hydrazide Schiff's bases 4a-4r were prepared starting from ethyl-4,4,4-trifluoroacetoacetate and ethyl carbazate in four steps. All the compounds were screened for antibacterial activity against various bacterial strains at 150 μg/ml concentration and found no activity. Similarly, all the compounds were screened for antifungal activity against various fungal strains at 100 and 150 μg/ml concentrations. Compounds 4a, 4m, and 4q found to show moderate activity against Candida albicans. Further, compounds were evaluated for cytotoxic activity against breast carcinoma cells MDA-MB 231 (aggressive), MCF-7 (non-aggressive) using doxorubicin as standard. Compound 4n was found to show 25.39 % cell viability against MDA-MB 231 and 63.60 % cell viability against MCF-7 cells.