1392278-33-9

Basic information

• Product Name: methyl 3-(4-[3-(4-aminophenyl)ureido]phenylaminomethyl)benzoate
• Synonyms: methyl 3-(4-[3-(4-aminophenyl)ureido]phenylaminomethyl)benzoate
• CAS NO: 1392278-33-9
• Molecular Weight: 390.442
• Mol File: 1392278-33-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: methyl 3-(4-[3-(4-aminophenyl)ureido]phenylaminomethyl)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 3-(4-[3-(4-aminophenyl)ureido]phenylaminomethyl)benzoate(1392278-33-9)
• EPA Substance Registry System: methyl 3-(4-[3-(4-aminophenyl)ureido]phenylaminomethyl)benzoate(1392278-33-9)

Safety Data

• Hazardous Substances Data: 1392278-33-9(Hazardous Substances Data)

Upstream product

• 4550-72-5 N,N'-bis(4-aminophenyl)urea 
• 52178-50-4 Methyl 3-formylbenzoate 
• 587-90-6 bis-N,N'-(4-nitrophenyl)urea 
• 100-28-7 4-Nitrophenyl isocyanate 

Relevant articles and documents

Discovery of 1-[4-(N-benzylamino)phenyl]-3-phenylurea derivatives as non-peptidic selective SUMO-sentrin specific protease (SENP)1 inhibitors

We developed 1-[4-(N-benzylamino)phenyl]-3-phenylurea derivative 4 (GN6958) as a non-peptidic selective SUMO-sentrin specific protease (SENP)1 protease inhibitor based on the hypoxia inducible factor (HIF)-1α inhibitor 1 (GN6767). The direct interaction of compound 1 with SENP1 protein in cells was observed by the pull-down experiments using the biotin-tagged compound 2 coated on the streptavidin affinity column. Among the various 1-[4-(N-benzylamino) phenyl]-3-phenylurea derivatives tested, compounds 3 and 4 suppressed HIF-1α accumulation in a concentration-dependent manner without affecting the expression level of tubulin protein in HeLa cells. Both compounds inhibited SENP1 protease activity in a concentration-dependent manner, and compound 4 exhibited more potent inhibition than compound 3. Compound 4 exhibited selective inhibition against SENP1 protease activity without inhibiting other protease enzyme activities in vitro.