1392490-96-8

Basic information

• Product Name: N-[1-({4-[(2-cyclohexylethyl)carbamoyl]benzene}sulfonyl)piperidin-4-yl]carbamic acid tert-butyl ester
• Synonyms: N-[1-({4-[(2-cyclohexylethyl)carbamoyl]benzene}sulfonyl)piperidin-4-yl]carbamic acid tert-butyl ester
• CAS NO: 1392490-96-8
• Molecular Weight: 493.668
• Mol File: 1392490-96-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-[1-({4-[(2-cyclohexylethyl)carbamoyl]benzene}sulfonyl)piperidin-4-yl]carbamic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-[1-({4-[(2-cyclohexylethyl)carbamoyl]benzene}sulfonyl)piperidin-4-yl]carbamic acid tert-butyl ester(1392490-96-8)
• EPA Substance Registry System: N-[1-({4-[(2-cyclohexylethyl)carbamoyl]benzene}sulfonyl)piperidin-4-yl]carbamic acid tert-butyl ester(1392490-96-8)

Safety Data

• Hazardous Substances Data: 1392490-96-8(Hazardous Substances Data)

Upstream product

• 73874-95-0 (piperidin-4-yl)carbamic acid tert-butyl ester 
• 10130-89-9 p-carboxyphenylsulfonyl chloride 
• 1251465-28-7 4-(4-tert-butoxycarbonylaminopiperidine-1-sulfonyl)benzoic acid 
• 5471-55-6 2-cyclohexylethan-1-amine hydrochloride 

Downstream Products

• 1392490-71-9 4-(4-Acryloylamino-piperidine-1-sulfonyl)-N-(2-cyclohexyl-ethyl)-benzamide 

Relevant articles and documents

Irreversible 4-aminopiperidine transglutaminase 2 inhibitors for Huntington's disease

A new series of potent TG2 inhibitors are reported that employ a 4-aminopiperidine core bearing an acrylamide warhead. We establish the structure-activity relationship of this new series and report on the transglutaminase selectivity and in vitro ADME properties of selected compounds. We demonstrate that the compounds do not conjugate glutathione in an in vitro setting and have superior plasma stability over our previous series.