1392498-76-8Relevant articles and documents
Direct electrophilic N-trifluoromethylation of azoles by a hypervalent iodine reagent
Niedermann, Katrin,Früh, Natalja,Senn, Remo,Czarniecki, Barbara,Verel, René,Togni, Antonio
supporting information; experimental part, p. 6511 - 6515 (2012/08/07)
Effective CF3 transfer: Various electron-rich nitrogen heterocycles (pyrazoles, triazoles, and tetrazoles) can be directly N-trifluoromethylated by a hypervalent iodine reagent in an efficient manner. The optimized procedure, which includes an in situ silylation of the substrate followed by an acid-catalyzed CF3 transfer, provides ready access to a series of new and previously challenging or inaccessible NCF3 compounds. Copyright