1392836-25-7

Basic information

• Product Name: 2-((2S,4S)-1,2,3,4-tetrahydro-6-methoxy-4-methyl-2-(4-nitrophenyl)quinolin-4-yl)phenol
• Synonyms: 2-((2S,4S)-1,2,3,4-tetrahydro-6-methoxy-4-methyl-2-(4-nitrophenyl)quinolin-4-yl)phenol
• CAS NO: 1392836-25-7
• Molecular Weight: 390.439
• Mol File: 1392836-25-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-((2S,4S)-1,2,3,4-tetrahydro-6-methoxy-4-methyl-2-(4-nitrophenyl)quinolin-4-yl)phenol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-((2S,4S)-1,2,3,4-tetrahydro-6-methoxy-4-methyl-2-(4-nitrophenyl)quinolin-4-yl)phenol(1392836-25-7)
• EPA Substance Registry System: 2-((2S,4S)-1,2,3,4-tetrahydro-6-methoxy-4-methyl-2-(4-nitrophenyl)quinolin-4-yl)phenol(1392836-25-7)

Safety Data

• Hazardous Substances Data: 1392836-25-7(Hazardous Substances Data)

Upstream product

• 10277-93-7 2-isopropenylphenol 
• 555-16-8 4-nitrobenzaldehdye 
• 104-94-9 4-methoxy-aniline 

Relevant articles and documents

An asymmetric organocatalytic povarov reaction with 2-hydroxystyrenes

An organocatalytic asymmetric three-component Povarov reaction involving 2-hydroxystyrenes has been established to provide an efficient method to access structurally diverse cis-disubstituted tetrahydroquinolines in high stereoselectivities of up to >99:1 dr and 97% ee. This protocol also provides an easy access to tetrahydroquinolines with chiral quaternary stereocenters upon using α-alkyl 2-hydroxystyrenes as substrates. The theoretical studies revealed that the Povarov reaction proceeded through a sequential vinylogous Mannich reaction and an intramolecular Friedel-Crafts reaction, wherein the phosphoric acid acted as bifunctional catalyst to activate 2-hydroxystyrene and aldimine simultaneously.