139301-27-2 Usage
Description
4-Trifluoromethoxyphenylboronic acid is a white to beige crystalline powder with chemical properties that make it a versatile reagent in the synthesis of various biologically active molecules.
Uses
Used in Pharmaceutical Industry:
4-Trifluoromethoxyphenylboronic acid is used as a reagent for the synthesis of orally bioavailable matrix metalloprotinase inhibitors, which are essential in the development of treatments for various medical conditions.
Used in Cancer Treatment:
4-Trifluoromethoxyphenylboronic acid is used as a reactant in the synthesis of lactate dehydrogenase inhibitors, which are crucial for inhibiting cancer cell proliferation.
Used in Enzyme Inhibition:
4-Trifluoromethoxyphenylboronic acid is used as a reactant in the preparation of nitro-phenoxybenzoic acid derivatives for PAI-1 inhibition, playing a significant role in the development of treatments for various diseases.
Used in Antituberculosis Drugs:
4-Trifluoromethoxyphenylboronic acid is used as a reactant in the synthesis of PA-824 analogs, which are utilized as antituberculosis drugs, contributing to the fight against tuberculosis.
Used in Neurodegenerative Disease Treatment:
4-Trifluoromethoxyphenylboronic acid is used as a reactant in the development of modulators of survival motor neuron protein, which are essential in the treatment of neurodegenerative diseases.
Used in Chemical Synthesis:
4-Trifluoromethoxyphenylboronic acid is used as a reactant involved in addition reactions and cross-coupling reactions, including the Suzuki-Miyaura cross-coupling, which is a widely used method in organic chemistry for the formation of carbon-carbon bonds.
Check Digit Verification of cas no
The CAS Registry Mumber 139301-27-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,9,3,0 and 1 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 139301-27:
(8*1)+(7*3)+(6*9)+(5*3)+(4*0)+(3*1)+(2*2)+(1*7)=112
112 % 10 = 2
So 139301-27-2 is a valid CAS Registry Number.
InChI:InChI=1/C7H6BF3O3/c9-7(10,11)14-6-3-1-5(2-4-6)8(12)13/h1-4,12-13H
139301-27-2Relevant articles and documents
Transition-Metal-Free Borylation of Aryl Bromide Using a Simple Diboron Source
Han, Min Su,Lim, Taeho,Ryoo, Jeong Yup
, p. 10966 - 10972 (2020/09/23)
In this study, we developed a simple transition-metal-free borylation reaction of aryl bromides. Bis-boronic acid (BBA), was used, and the borylation reaction was performed using a simple procedure at a mild temperature. Under mild conditions, aryl bromides were converted to arylboronic acids directly without any deprotection steps and purified by conversion to trifluoroborate salts. The functional group tolerance was considerably high. The mechanism study suggested that this borylation reaction proceeds via a radical pathway.
2,3,4,5-TETRAHYDRO-1H-1,5-BENZODIAZEPINE DERIVATIVE AND MEDICINAL COMPOSITION
-
, (2008/06/13)
The present invention has its object to provide a 2,3,4,5-tetrahydro-1H-1,5-benzodiazepine derivative represented with the Formula (1) , or the pharmaceutically acceptable salt, which is effective as a therapeutic and prophylactic agent for diabetes, diabetic nephropathy, or glomerulosclerosis.
Process for the preparation of matrix metalloproteinase inhibitors
-
, (2008/06/13)
The instant invention provides a process for the synthesis of matrix metalloproteinase inhibitors.
