1393109-24-4

Basic information

• Product Name: bis[1-ethyl-4,5-bis(4-methoxyphenyl)-1H-imidazol-2-yl]methane
• Synonyms: bis[1-ethyl-4,5-bis(4-methoxyphenyl)-1H-imidazol-2-yl]methane
• CAS NO: 1393109-24-4
• Molecular Weight: 628.771
• Mol File: 1393109-24-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: bis[1-ethyl-4,5-bis(4-methoxyphenyl)-1H-imidazol-2-yl]methane(CAS DataBase Reference)
• NIST Chemistry Reference: bis[1-ethyl-4,5-bis(4-methoxyphenyl)-1H-imidazol-2-yl]methane(1393109-24-4)
• EPA Substance Registry System: bis[1-ethyl-4,5-bis(4-methoxyphenyl)-1H-imidazol-2-yl]methane(1393109-24-4)

Safety Data

• Hazardous Substances Data: 1393109-24-4(Hazardous Substances Data)

Upstream product

• 3363-51-7 1-ethyl-4,5-bis(4-methoxyphenyl)-1H-imidazole 
• 119-52-8 4,4'-dimethoxybenzoin 
• 123-11-5 4-methoxy-benzaldehyde 
• 22397-48-4 4,5-bis(4-methoxyphenyl)-1H-imidazole 
• 1393109-22-2 bis[1-ethyl-4,5-bis(4-methoxyphenyl)-1H-imidazol-2-yl]methanone 

Downstream Products

• 1393109-28-8 bis[1-ethyl-4,5-bis(4-hydroxyphenyl)-1H-imidazol-2-yl]methane 

Relevant articles and documents

Synthesis, antitumor, and antibacterial activity of Bis[4,5-diarylimidazol- 2-ylidene]methane derivatives

Cationic [bis(1,3-diethyl-4,5-diarylimidazol-2-ylidene)]Au(I) bromide complexes have demonstrated considerable potential as new antitumor agents. In order to investigate whether the gold is crucial for the antitumor activity, the imidazole ligands were connected by a methylene bridge. Biological evaluation revealed that bis[1,3-diethyl-4,5-diarylimidazol-2-ylidene]methane compounds exhibited growth inhibition effects against mammary (MCF-7 and MDA-MB 231) and colon (HT-29) carcinoma cell lines. In comparison with gold complexes, the methylene derivatives showed drastically reduced cell growth inhibitory properties. However, the growth of bacteria was significantly inhibited by bis[1,3-diethyl-4,5-bis(4-methoxyphenyl)imidazol-2-ylidene]methane dibromide (4) and opens a new application of this compound type. To investigate whether the gold in cationic [bis(1,3-diethyl-4,5-diarylimidazol-2-ylidene)]Au(I) bromide complexes is crucial for their antitumor activity, the imidazole ligands were connected by a methylene bridge. In comparison with the gold complexes, the methylene derivatives showed drastically reduced cell growth inhibitory properties. However, the growth of bacteria was significantly inhibited by bis[1,3-diethyl-4,5-bis(4-methoxyphenyl)imidazol-2-ylidene]methane dibromide (4), opening a new application of this compound type. Copyright