1393123-19-7

Basic information

• Product Name: 4-[¹⁸F]fluoro-2-methylphenol
• CAS NO: 1393123-19-7
• Molecular Weight: 125.132
• Mol File: 1393123-19-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-[¹⁸F]fluoro-2-methylphenol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[¹⁸F]fluoro-2-methylphenol(1393123-19-7)
• EPA Substance Registry System: 4-[¹⁸F]fluoro-2-methylphenol(1393123-19-7)

Safety Data

• Hazardous Substances Data: 1393123-19-7(Hazardous Substances Data)

Upstream product

• 493035-82-8 (2-methyl-4-hydroxyphenyl)boronic acid 
• 946427-03-8 4,4,5,5-tetramethyl-2-(2-methyl-4-hydroxyphenyl)-1,3,2-dioxaborolane 
• 2219-72-9 4-tert-butyl-3-methyl-phenol 

Relevant articles and documents

Alcohol-Enhanced Cu-Mediated Radiofluorination

The potential of many 18F-labeled (hetero)aromatics for applications in positron emission tomography remains underexplored because convenient procedures for their radiosynthesis are lacking. Consequently, simple methods to prepare radiofluorinated (hetero)arenes are highly sought after. Herein, we report the beneficial effect of primary and secondary alcohols on Cu-mediated 18F-labeling. This observation contradicts the assumption that such alcohols are inappropriate solvents for aromatic fluorination. Therefore, we developed a protocol for rapid radiolabeling of an extraordinarily broad scope of boronic and stannyl substrates under general reaction conditions. Notably, radiofluorinated indoles, phenols, and anilines were synthesized directly from the corresponding unprotected precursors. Furthermore, the novel method enabled the preparation of radiofluorinated tryptophans, [18F]F-DPA, [18F]DAA1106, 6-[18F]FDA, and 6-[18F]FDOPA.