139326-10-6

Basic information

• Product Name: Thieno[2,3-b]pyridine-2-carbonitrile, 3-amino-6-phenyl-
• CAS NO: 139326-10-6
• Molecular Formula: C14H9N3S
• Molecular Weight: 251.312
• Mol File: 139326-10-6.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Thieno[2,3-b]pyridine-2-carbonitrile, 3-amino-6-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Thieno[2,3-b]pyridine-2-carbonitrile, 3-amino-6-phenyl-(139326-10-6)
• EPA Substance Registry System: Thieno[2,3-b]pyridine-2-carbonitrile, 3-amino-6-phenyl-(139326-10-6)

Safety Data

• Hazardous Substances Data: 139326-10-6(Hazardous Substances Data)

Upstream product

• 107-14-2 chloroacetonitrile 
• 92126-72-2 2-mercapto-6-phenylpyridine-3-carbonitrile 
• 69750-01-2 2-chloro-6-phenylpyridine-3-carboxylic acid 
• 43083-14-3 2-chloro-3-cyano-6-phenylpyridine 
• 38496-18-3 2,6-dichloropyridine-3-carboxylic acid 
• 98-80-6 phenylboronic acid 
• 92126-72-2 6-phenyl-2-thioxo-1,2-dihydropyridine-3-carbonitrile 
• 709643-53-8 2-[(cyanomethyl)sulfanyl]-6-phenylpyridine-3-carbonitrile 

Downstream Products

• 1374993-43-7 4-imino-3,7-diphenyl-3,4-dihydropyrido[3',2':4,5]thieno[3,2-d]pyramidine-2(1H)-thione 
• 139326-33-3 2-Methyl-9-phenyl-pyrido<3',2':4,5>thieno<2,3-e>1,2,4-triazolo<2,3-c>pyrimidin 
• 139359-09-4 9-Phenyl-pyrido<3',2':4,5>thieno<2,3-e>1,2,4-triazolo<2,3-c>pyrimidin 
• 139326-16-2 3-Amino-4-imino-3,4-dihydro-7-phenyl-pyrido<3',2':4,5>thieno<3,2-d>pyrimidin 
• 141278-13-9 3-Amino-2-(3,4,5,6-tetrahydropyrimidin-2-yl)-6-phenylthieno<2,3-b>pyridin 
• 139326-13-9 3-Ethoxymethylenamino-6-phenyl-thieno<2,3-b>pyridin-2-carbonitril 
• 141278-08-2 3-Amino-2-(imidazolin-2-yl)-6-phenyl-thieno<2,3-b>pyridin 
• 141278-05-9 3-Amino-6-phenyl-thieno<2,3-b>pyridin-2-thiocarbonsaeureamid 

Relevant articles and documents

INHIBITORS OF MICROBIAL BETA-GLUCURONIDASE ENZYMES AND USES THEREOF

Compounds and compositions are provided that comprise selective b-glucuronidase inhibitors. The compounds and compositions can ameliorate the side effects of chemotherapeutic agents and can improve the efficacy of such agents, including irinotecan and non-steroidal anti-inflammatory drugs.

PYRIDO [3',2' :4,5] THIENO [3, 2-D] PYRIMIDIN- 4 - YLAMINE DERIVATIVES AND THEIR THERAPEUTICAL USE

The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain fused triaryl amine compounds of the following formula (for convenience, collectively referred to herein as "FTA compounds"), which, inter alia, inhibit LIM kinase (LIMK) activity. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit LIMK activity, and in the treatment of diseases and conditions that are mediated by LIMK, that are ameliorated by the inhibition of LIMK activity, etc., including proliferative conditions such as cancer (e.g., breast cancer, prostate cancer, melanoma, glioma, etc.), as well as vasodilation (including, e.g., hypertension, angina, cerebral vasospasm, and ischemia following subarachnoid hemorrhage), neurodegenerative disorders, atherosclerosis, fibrosis, and inflammatory diseases (including, e.g., Crohn's disease and chronic obstructive pulmonary disease (COPD)), and glaucoma (also known as ocular hypertension).

Synthesis of imidazoline-2-yl- and of 3,4,5,6-tetrahydropyrimidine-2-yl-3-amino-thieno[2,3-b]pyridines

The imidazoline and the tetrahydropyrimidine derivatives of the thieno[2,3-b]pyridines were prepared by the reaction of diaminoalkanes and carbondisulfide with the aminothieno-[2,3-b]pyridines 3 or from cyanomethylthiopyridines 2, or from aminothieno[2,3-