139348-57-5

Basic information

• Product Name: Benzo[b]thiophene-2-carboxamide, N-(6-amino-1,2,3,4-tetrahydro-2,4-dioxo-1,3-dipropyl-5-pyrimidinyl)-
• Synonyms: Benzo[b]thiophene-2-carboxamide, N-(6-amino-1,2,3,4-tetrahydro-2,4-dioxo-1,3-dipropyl-5-pyrimidinyl)-
• CAS NO: 139348-57-5
• Molecular Formula: C19H22N4O3S
• Molecular Weight: 0
• Mol File: 139348-57-5.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzo[b]thiophene-2-carboxamide, N-(6-amino-1,2,3,4-tetrahydro-2,4-dioxo-1,3-dipropyl-5-pyrimidinyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzo[b]thiophene-2-carboxamide, N-(6-amino-1,2,3,4-tetrahydro-2,4-dioxo-1,3-dipropyl-5-pyrimidinyl)-(139348-57-5)
• EPA Substance Registry System: Benzo[b]thiophene-2-carboxamide, N-(6-amino-1,2,3,4-tetrahydro-2,4-dioxo-1,3-dipropyl-5-pyrimidinyl)-(139348-57-5)

Safety Data

• Hazardous Substances Data: 139348-57-5(Hazardous Substances Data)

Upstream product

• 39827-11-7 benzothiophene-2-carboxylic acid chloride 
• 81250-34-2 1,3-dipropyl-5,6-diaminouracil 

Relevant articles and documents

8-Polycycloalkyl-1,3-dipropylxanthines as potent and selective antagonists for A1-adenosine receptors

With the aim of characterizing the hydrophobic interactions between xanthines and the A1 receptor site, 1,3-dipropyl-8-substituted xanthines were synthesized. Introduction of a quaternary carbon and the conformationally restricted cyclopentyl moiety into the 8-position of xanthines enhanced the adenosine A1 antagonism. 1,3-Dipropyl-8-(3- noradamantyl)xanthine (42) was identified to be a selective and the most potent A1 receptor antagonist reported to date. Under our structure-activity relationship, the 8-substituent of xanthine antagonists and the N6- substituent of adenosine agonists appears to bind to the same region of the A1 receptor.