1393645-67-4

Basic information

• Product Name: C₂₁H₂₃NO₃
• CAS NO: 1393645-67-4
• Molecular Weight: 337.419
• Mol File: 1393645-67-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₁H₂₃NO₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₁H₂₃NO₃(1393645-67-4)
• EPA Substance Registry System: C₂₁H₂₃NO₃(1393645-67-4)

Safety Data

• Hazardous Substances Data: 1393645-67-4(Hazardous Substances Data)

Upstream product

• 21557-09-5 N-(4-acetylphenyl)pyrrolidine 
• 120-14-9 3,4-dimethoxy-benzaldehyde 

Relevant articles and documents

Antimalarial Activity of Newly Synthesized Chalcone Derivatives In Vitro

Twenty-seven novel chalcone derivatives were synthesized using Claisen-Schmidt condensation and their antimalarial activity against asexual blood stages of Plasmodium falciparum was determined. Antiplasmodial IC50 (half-maximal inhibitory concentration) activity of a compound against malaria parasites in vitro provides a good first screen for identifying the antimalarial potential of the compound. The most active compound was 1-(4-benzimidazol-1-yl-phenyl)-3-(2, 4-dimethoxy-phenyl)-propen-1-one with IC50 of 1.1μg/mL, while that of the natural phytochemical, licochalcone A is 1.43μg/mL. The presence of methoxy groups at position 2 and 4 in chalcone derivatives appeared to be favorable for antimalarial activity as compared to other methoxy-substituted chalcones. Furthermore, 3, 4, 5-trimethoxy groups on chalcone derivative probably cause steric hindrance in binding to the active site of cysteine protease enzyme, explaining the relative lower inhibitory activity.