139413-82-4

Basic information

• Product Name: 2-Propenenitrile, 2-(bromomethyl)-3-phenyl-, (Z)-
• CAS NO: 139413-82-4
• Molecular Formula: C10H8BrN
• Molecular Weight: 222.084
• Mol File: 139413-82-4.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: 2-Propenenitrile, 2-(bromomethyl)-3-phenyl-, (Z)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenenitrile, 2-(bromomethyl)-3-phenyl-, (Z)-(139413-82-4)
• EPA Substance Registry System: 2-Propenenitrile, 2-(bromomethyl)-3-phenyl-, (Z)-(139413-82-4)

Safety Data

• Hazardous Substances Data: 139413-82-4(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 19362-96-0 2-(1-hydroxybenzyl)acrylonitrile 
• 120696-98-2 2-hydroxymethyl-3t-phenyl-acrylonitrile 
• 92287-34-8 (Z)-2-cyano-3-methoxy-1-phenylprop-1-ene 

Downstream Products

• 1010396-73-2 (E)-2-((2-formylphenoxy)methyl)-3-phenylacrylonitrile 
• 1393805-87-2 C₁₆H₁₄N₂O₂ 
• 1334333-57-1 C₁₇H₁₆N₂ 
• 1334333-62-8 C₁₇H₁₆N₂ 
• 1334333-51-5 2-methylene-3-phenyl-4-(pyridin-2-yl)butanenitrile 
• 1228955-20-1 2-(4-methylbenzyl)-3-phenylacrylonitrile 
• 1190078-58-0 C₁₅H₁₈NO₂PS 

Relevant articles and documents

Design, Synthesis, and Biological Evaluation of Organic Nitrite (NO 2-) Donors as Potential Anticerebral Ischemia Agents

The treatment of ischemic stroke (IS) remains a big challenge in clinics, and it is urgently needed to develop novel, safe, and effective medicines against IS. Here, we report the design, synthesis, and biological evaluation of organic NO2- donors as potential agents for the treatment of IS. The representative compound 4a was able to slowly generate low concentrations of NO2- by reaction with a thiol-containing nucleophile, and the NO2- was selectively converted into NO under ischemic/hypoxia conditions to protect primary rat neurons from oxygen-glucose deprivation and recovery (OGD/R)-induced cytotoxicity by enhancing the Nrf2 signaling and activating the NO/cGMP/PKG pathway. Treatment with 4a at 2 h before or after ischemia mitigated the ischemia/reperfusion-induced brain injury in middle cerebral artery occlusion (MCAO) rats by producing NO and enhancing Nrf2 signaling. Furthermore, 4a significantly promoted endothelial cell proliferation and angiogenesis within the ischemic penumbra. Our findings suggest that this type of NO2- donors, like 4a, may be valuable to fight IS and other ischemic diseases.

Pd(0)-catalyzed couplings using bromide and chloride derivatives of Baylis-Hillman adducts with triarylbismuths as atom-efficient multi-coupling nucleophiles

Bromide and chloride derivatives of Baylis-Hillman adducts have been demonstrated to react efficiently with triarylbismuths affording allylic arylated products in high yields under palladium-catalyzed conditions. Triarylbismuths have been employed in sub-stoichiometric amounts as multi-coupling and atom-efficient nucleophiles in these reactions. The reactivity of both allylic bromides and chlorides was found to be facile and equally efficient in couplings with triarylbismuths.

Mild and practical stereoselective synthesis of (Z)- and (E)-allyl bromides from Baylis-Hillman adducts using Appel agents (PPh3/CBr4): a facile synthesis of semiplenamides C and E

Appel agents (PPh3/CBr4) have been utilized for high-yielding stereoselective synthesis of (Z)- and (E)-allyl bromides from Baylis-Hillman adducts at room temperature. The method has been applied for the synthesis of naturally occurr