1394140-28-3

Basic information

• Product Name: 3-(5-(4-amino-2-hydroxyphenyl)-1,3,4-oxadiazol-2-yl)-1-(1H-benzo[d]imidazol-2-yl)propan-1-one
• CAS NO: 1394140-28-3
• Molecular Weight: 349.349
• Mol File: 1394140-28-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(5-(4-amino-2-hydroxyphenyl)-1,3,4-oxadiazol-2-yl)-1-(1H-benzo[d]imidazol-2-yl)propan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(5-(4-amino-2-hydroxyphenyl)-1,3,4-oxadiazol-2-yl)-1-(1H-benzo[d]imidazol-2-yl)propan-1-one(1394140-28-3)
• EPA Substance Registry System: 3-(5-(4-amino-2-hydroxyphenyl)-1,3,4-oxadiazol-2-yl)-1-(1H-benzo[d]imidazol-2-yl)propan-1-one(1394140-28-3)

Safety Data

• Hazardous Substances Data: 1394140-28-3(Hazardous Substances Data)

Upstream product

• 95-54-5 1,2-diamino-benzene 
• 328-50-7 α-ketoglutaric acid 
• 1394139-93-5 4-(1H-benzo[d]-imidazole-2-yl)-4-oxobutanoic acid 

Relevant articles and documents

Synthesis of benzimidazoles bearing oxadiazole nucleus as anticancer agents

Starting from 4-(1H-benzo[d]imidazol-2-yl)-4-oxobutanehydrazide (1), twenty new 1-(1H-benzo[d]imidazol-2-yl)-3-(1,3,4-oxadiazol-5-substituted derivatives-2-yl)propan-1-ones (1b-A7-26) were synthesized under microwave irradiation in good yields. Further, compound 1b-A7 was reacted with different secondary amines under microwave irradiation to produce five novel 1-(1H-benzo[d]imidazol-2-yl)-3-(5-(methyl substituted)-1,3,4-oxadiazol-2-yl)propan-1-ones (1b-A7a -e). The title compounds were screened for their in vitro anticancer activity at National Cancer Institute (NCI), USA; at a single dose (10 μM) in NCI 60 cell line panel and results showed significant to good anticancer activity. One compound, 1b-A18 (NSC: 759205), 1-(1H-benzo[d]imidazol-2-yl)-3-(5-(2,4-dichlorophenyl)-1,3,4-oxadiazol-2-yl) propan-1-one, emerged as lead compound; it was selected for five-dose level screening and found to have significant growth inhibition activity.