1394141-09-3Relevant articles and documents
Synthesis of some novel thiocyanotopurine derivatives and investigation of their antimicrobial activity and DNA interactions
Celik, Guelay Dilek,Disli, A Ali,Oener, Yagmur,Acik, Leyla
, p. 578 - 582 (2012/07/13)
A series of 6-thiocyanatopurine derivatives introduced with different alkyl groups in position 9 was synthesized. The structures of the synthesized compounds were evaluated via spectroscopic methods and elemental methods of analyses. All the synthesized compounds were screened for their antibacterial activities against Gram-positive and Gram-negative bacteria and for their antifungal activities against yeast strains. All the synthesized compounds showed better antibacterial activities against Gram-positive bacteria compared to Gram-negative bacteria. DNA interactions with pBR322 DNA were determined. Most of the compounds caused conformational changes in DNA.